Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sydow, K.; Schmitz, C.; von Leitner, E.C.; von Leitner, R.; Klinke, A.; Atzler, D.; Krebs, C.; Wieboldt, H.; Ehmke, H.; Schwedhelm, E.; Meinertz, T.; Blankenberg, S.; Boeger, R.H.; Magnus, T.; Baldus, S.; Wenzel, U.
    Dimethylarginine dimethylaminohydrolase1 is an organ-specific mediator of end organ damage in a murine model of hypertension (2012), PLoS ONE, 7, e48150.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.3.18 expressed in Mus musculus Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.3.18 Nomega,Nomega'-dimethyl-L-arginine + H2O Homo sapiens
-
 dimethylamine + L-citrulline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.18 Homo sapiens O94760
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.18 Nomega,Nomega'-dimethyl-L-arginine + H2O
-
 Homo sapiens dimethylamine + L-citrulline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.3.18 DDAH1
-
 Homo sapiens
3.5.3.18 dimethylarginine dimethylaminohydrolase1
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.5.3.18 physiological function human DDAH1 overexpression does not protect against hypertension-induced cardiac fibrosis and hypertrophy. In addition, the hypertension-induced impairment of the endothelium-dependent vasorelaxation of aortic segments ex vivo is not significantly attenuated by DDAH1 overexpression. However, human DDAH1 overexpressing mice display an attenuated hypertensive inflammatory response in renal tissue, resulting in less hypertensive renal injury Homo sapiens