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Literature summary extracted from

  • Li, Y.; Yang, L.; Chen, L.; Zhu, C.; Huang, R.; Zheng, X.; Qiu, Y.; Fu, J.
    Design and synthesis of potent N-acylethanolamine-hydrolyzing acid amidase (NAAA) inhibitor as anti-inflammatory compounds (2012), PLoS ONE, 7, e43023.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.5.1.60 recombinant expression of the enzyme in HEK-293 cells Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.60 ([1,1'-biphenyl]-4-yl)methyl cyclopentanecarboxylate
-
 Rattus norvegicus
3.5.1.60 1-(2-(4-benzyloxy)phenyl)ethyl-carbonyl pyrrolidine
-
 Rattus norvegicus
3.5.1.60 1-(2-biphenyl-4-yl)ethyl-carbonyl pyrrolidine
-
 Rattus norvegicus
3.5.1.60 1-(2-naphthalenyl)acetyl pyrrolidine
-
 Rattus norvegicus
3.5.1.60 1-(2-naphthalenyl)carbonyl pyrrolidine
-
 Rattus norvegicus
3.5.1.60 1-(2-phenylethyl)-carbonyl pyrrolidine
-
 Rattus norvegicus
3.5.1.60 1-(3-phenylpropanyl)-carbonyl pyrrolidine
-
 Rattus norvegicus
3.5.1.60 1-(4-benzyloxy)benzyl-carbonyl pyrrolidine
-
 Rattus norvegicus
3.5.1.60 1-(4-phenylbenzyl)-carbonyl pyrrolidine
-
 Rattus norvegicus
3.5.1.60 1-(4-phenylbutanyl)-carbonyl pyrrolidine
-
 Rattus norvegicus
3.5.1.60 1-(5-phenylpentanyl)-carbonyl pyrrolidine
-
 Rattus norvegicus
3.5.1.60 1-(6-phenylhexanyl)-carbonyl pyrrolidine
-
 Rattus norvegicus
3.5.1.60 1-(7-phenylheptanyl)-carbonyl pyrrolidine
-
 Rattus norvegicus
3.5.1.60 1-(biphenyl-4-ylcarbonyl)pyrrolidine
-
 Rattus norvegicus
3.5.1.60 1-benzyl-carbonyl pyrrolidine
-
 Rattus norvegicus
3.5.1.60 1-pentadecanyl-carbonyl piperidine
-
 Rattus norvegicus
3.5.1.60 1-pentadecanyl-carbonyl pyrrole
-
 Rattus norvegicus
3.5.1.60 1-pentadecanyl-carbonyl pyrrolidine
-
 Rattus norvegicus
3.5.1.60 1-[3-([1,1'-biphenyl]-4-yl)propyl]pyrrolidine
-
 Rattus norvegicus
3.5.1.60 biphenyl-4-ylmethyl pyrrolidinyl-1-carboxylate
-
 Rattus norvegicus
3.5.1.60 cyclopentyl palmitate
-
 Rattus norvegicus
3.5.1.60 additional information design and synthesis of potent N-acylethanolamine-hydrolyzing acid amidase inhibitors, derivatives of 1-pentadecanyl-carbonyl pyrrolidine, as anti-inflammatory compounds, computational docking analysis, structure-activity relationship, overview Rattus norvegicus
3.5.1.60 N-(biphenyl-4-ylmethyl)pyrrolidinyl-1-carboxamide
-
 Rattus norvegicus
3.5.1.60 N-cyclopentylpalmitamide
-
 Rattus norvegicus
3.5.1.60 N-[([1,1'-biphenyl]-4-yl)methyl]cyclopentanecarboxamide
-
 Rattus norvegicus
3.5.1.60 tetrahydrofuran-3-yl palmitate
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.60 lysosome
-
 Rattus norvegicus 5764
-

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.60 Rattus norvegicus Q5KTC7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.60 (10Z)-heptadecenoylethanolamide + H2O
-
 Rattus norvegicus (10Z)-heptadec-10-enoic acid + ethanolamine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.60 N-acylethanolaminehydrolyzing acid amidase
-
 Rattus norvegicus
3.5.1.60 NAAA
-
 Rattus norvegicus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.1.60 37
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.60 5
-
 assay at Rattus norvegicus