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Literature summary extracted from

  • Choi, M.Y.; Wang, Y.; Wong, L.L.; Lu, B.T.; Chen, W.Y.; Huang, J.D.; Tanner, J.A.; Watt, R.M.
    The two PPX-GppA homologues from Mycobacterium tuberculosis have distinct biochemical activities (2012), PLoS ONE, 7, e42561.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.11 expression in Escherichia coli Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.11 Guanosine 5'-pentaphosphate 1 mM, 73% resiudal activity Mycobacterium tuberculosis
3.6.1.11 guanosine 5'-tetraphosphate 1 mM, 68% resiudal activity Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.11 0.0059
-
 (polyphosphate)14 pH 6.8, 37°C Mycobacterium tuberculosis
3.6.1.11 0.0121
-
 (polyphosphate)60 pH 6.8, 37°C Mycobacterium tuberculosis
3.6.1.11 0.0173
-
 (polyphosphate)130 pH 6.8, 37°C Mycobacterium tuberculosis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.1.11 Mg2+ may partly substitute for Mn2+ Mycobacterium tuberculosis
3.6.1.11 Mn2+ required, optimum concentration 1 mM Mycobacterium tuberculosis
3.6.1.11 additional information no activity with Ca2+, Co2+, Cu2+ or Fe2+ ions Mycobacterium tuberculosis
3.6.1.11 Zn2+ may partly substitute for Mn2+ Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.11 Mycobacterium tuberculosis P9WHV5
-
-
3.6.1.11 Mycobacterium tuberculosis H37Rv P9WHV5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.11 (polyphosphate)130 + H2O
-
 Mycobacterium tuberculosis (polyphosphate)129 + phosphate
-
 ?
3.6.1.11 (polyphosphate)130 + H2O
-
 Mycobacterium tuberculosis H37Rv (polyphosphate)129 + phosphate
-
 ?
3.6.1.11 (polyphosphate)14 + H2O
-
 Mycobacterium tuberculosis (polyphosphate)13 + phosphate
-
 ?
3.6.1.11 (polyphosphate)14 + H2O
-
 Mycobacterium tuberculosis H37Rv (polyphosphate)13 + phosphate
-
 ?
3.6.1.11 (polyphosphate)60 + H2O
-
 Mycobacterium tuberculosis (polyphosphate)59 + phosphate
-
 ?
3.6.1.11 (polyphosphate)60 + H2O
-
 Mycobacterium tuberculosis H37Rv (polyphosphate)59 + phosphate
-
 ?
3.6.1.11 additional information no substrate: guanosine pentaphosphate. Enzyme hydrolyzes ATP and ADP, but lacks GTPase activities Mycobacterium tuberculosis ?
-
 ?
3.6.1.11 additional information no substrate: guanosine pentaphosphate. Enzyme hydrolyzes ATP and ADP, but lacks GTPase activities Mycobacterium tuberculosis H37Rv ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.1.11 Rv0496
-
 Mycobacterium tuberculosis

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.6.1.11 6.7
-
 (polyphosphate)130 pH 6.8, 37°C Mycobacterium tuberculosis
3.6.1.11 7.3
-
 (polyphosphate)60 pH 6.8, 37°C Mycobacterium tuberculosis
3.6.1.11 10.2
-
 (polyphosphate)14 pH 6.8, 37°C Mycobacterium tuberculosis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.6.1.11 6.8
-
-
 Mycobacterium tuberculosis

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
3.6.1.11 387
-
 (polyphosphate)130 pH 6.8, 37°C Mycobacterium tuberculosis
3.6.1.11 603
-
 (polyphosphate)60 pH 6.8, 37°C Mycobacterium tuberculosis
3.6.1.11 1729
-
 (polyphosphate)14 pH 6.8, 37°C Mycobacterium tuberculosis