Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Sun, C.; Fang, H.; Xie, T.; Auth, R.; Patel, N.; Murray, P.; Snoy, P.; Frucht, D.
    Anthrax lethal toxin disrupts intestinal barrier function and causes systemic infections with enteric bacteria (2012), PLoS ONE, 7, e33583.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.4.24.83 medicine in a murine model of intoxication, lethal factor causes the dose-dependent disruption of intestinal epithelial integrity, characterized by mucosal erosion, ulceration, and bleeding. The pathology correlates with a blockade of intestinal crypt cell proliferation, accompanied by marked apoptosis in the villus tips. Treated mice nearly uniformly develop systemic infections with commensal enteric organisms within 72 hours of administration. Intestinal pathology depends upon lethal factor proteolytic activity and is partially attenuated by co-administration of broad spectrum antibiotics Bacillus anthracis

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.83 Bacillus anthracis P15917
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

General Information

EC Number General Information Comment Organism
3.4.24.83 physiological function in a murine model of intoxication, lethal factor causes the dose-dependent disruption of intestinal epithelial integrity, characterized by mucosal erosion, ulceration, and bleeding. The pathology correlates with a blockade of intestinal crypt cell proliferation, accompanied by marked apoptosis in the villus tips. Treated mice nearly uniformly develop systemic infections with commensal enteric organisms within 72 hours of administration. Intestinal pathology depends upon lethal factor proteolytic activity and is partially attenuated by co-administration of broad spectrum antibiotics Bacillus anthracis