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Literature summary extracted from

  • Tresaugues, L.; Lundbaeck, T.; Welin, M.; Flodin, S.; Nyman, T.; Silvander, C.; Graeslund, S.; Nordlund, P.
    Structural basis for the specificity of human NUDT16 and its regulation by inosine monophosphate (2015), PLoS ONE, 10, e0131507.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.6.1.64
-
 Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.6.1.64 mutant A22V,structure forms an alpha/beta/alpha sandwich which is constituted by two beta-sheets, one being composed of two parallel beta-strands lined by two anti-parallel beta-strands and the second one by three anti-parallel beta-strands. The protein is decorated with five additional motifs being part of the hydrophobic core or serving roles to stabilize the dimer Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
3.6.1.64 A22V crystallization data Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.1.64 ADP
-
 Homo sapiens
3.6.1.64 GDP
-
 Homo sapiens
3.6.1.64 IDP
-
 Homo sapiens
3.6.1.64 IMP product inhibition Homo sapiens
3.6.1.64 ITP
-
 Homo sapiens
3.6.1.64 XDP
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.6.1.64 0.0062
-
 XDP pH 7.5, 37°C Homo sapiens
3.6.1.64 0.0082
-
 ITP pH 7.5, 37°C Homo sapiens
3.6.1.64 0.285
-
 ADP pH 7.5, 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.6.1.64 Homo sapiens Q96DE0
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.1.64 ADP + H2O
-
 Homo sapiens AMP + phosphate
-
 ?
3.6.1.64 ITP + H2O
-
 Homo sapiens IDP + phosphate
-
 ?
3.6.1.64 additional information rate of the catalytic cycle is primarily regulated by the product-release step Homo sapiens ?
-
 ?
3.6.1.64 XDP + H2O
-
 Homo sapiens XMP + phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
3.6.1.64 dimer crystallization data Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.6.1.64 U8 snoRNA-decapping enzyme
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.6.1.64 0.006
-
 XDP pH 7.5, 37°C Homo sapiens
3.6.1.64 0.013
-
 ITP pH 7.5, 37°C Homo sapiens
3.6.1.64 0.096
-
 ADP pH 7.5, 37°C Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.6.1.64 0.0098
-
 IMP substrate IDP, pH 7.5, 37°C Homo sapiens
3.6.1.64 0.0163
-
 IMP substrate IDP, pH 7.5, 37°C Homo sapiens
3.6.1.64 0.0213
-
 IMP substrate GDP, pH 7.5, 37°C Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.6.1.64 0.024
-
 substrate IDP, pH 7.5, 37°C Homo sapiens IMP
3.6.1.64 0.795
-
 substrate GDP, pH 7.5, 37°C Homo sapiens IMP
3.6.1.64 3.174
-
 substrate IDP, pH 7.5, 37°C Homo sapiens IMP

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
3.6.1.64 0.52
-
 ADP pH 7.5, 37°C Homo sapiens
3.6.1.64 0.99
-
 XDP pH 7.5, 37°C Homo sapiens
3.6.1.64 1.55
-
 ITP pH 7.5, 37°C Homo sapiens