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Literature summary extracted from

  • Aerne, B.L.; Gailite, I.; Sims, D.; Tapon, N.
    Hippo stabilises its adaptor Salvador by antagonising the HECT ubiquitin ligase Herc4 (2015), PLoS ONE, 10, e0131113.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.26 Drosophila melanogaster
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-
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2.3.2.26 Drosophila melanogaster S2
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.26 S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [Sav]-L-lysine Sav i.e. scaffold protein Salvador, believed to promote Hpo/Wts association Drosophila melanogaster [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[Sav]-L-lysine
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 ?
2.3.2.26 S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [Sav]-L-lysine Sav i.e. scaffold protein Salvador, believed to promote Hpo/Wts association Drosophila melanogaster S2 [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[Sav]-L-lysine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.3.2.26 Herc4
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 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
2.3.2.26 physiological function isoform Herc4 expression promotes scaffold protein Sav ubiquitylation and degradation, while Herc4 depletion stabilises Sav. Sav-binding protein Hpo reduces Sav/Herc4 interaction in a kinase-dependent manner Drosophila melanogaster