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Literature summary extracted from

  • Moss, C.X.; Brown, E.; Hamilton, A.; Van der Veken, P.; Augustyns, K.; Mottram, J.C.
    An essential signal peptide peptidase identified in an RNAi screen of serine peptidases of Trypanosoma brucei (2015), PLoS ONE, 10, e0123241.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.B24 Trypanosoma brucei
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Synonyms

EC Number Synonyms Comment Organism
3.4.23.B24 SPP1
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Trypanosoma brucei

General Information

EC Number General Information Comment Organism
3.4.23.B24 physiological function type-I signal peptide peptidase SPP1 is essential for parasite survival both in vitro and in vivo. Expression of catalytically inactive SPP1 is unable to rescue cells from the SPP1 depleted phenotype Trypanosoma brucei