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Literature summary extracted from
- Probing ADAMTS13 substrate specificity using phage display (2015), PLoS ONE, 10, e0122931.
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.87 | Homo sapiens | Q76LX8 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.87 | von Willebrand factor + H2O | - |
Homo sapiens | 2 peptides of 140 kDa and 176 kDa | ADAMTS13 cleaves von Willebrand factor at the Y1605/M1606 peptide bond in the A2 domain. Mutant substrates L1603Q, L1603R, Y1605D, L1603R/Y1605N, Y1605N/M1606T, Y1605R/M1606T are resistant to cleavage. Mutant substrates R1597W, M1606T and I1616N are less efficiently cleaved than wild-type | ? |  |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.87 | 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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