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Literature summary extracted from

  • Ma, P.; Schultz, R.M.
    Histone deacetylase 2 (HDAC2) regulates chromosome segregation and kinetochore function via H4K16 deacetylation during oocyte maturation in mouse (2013), PLoS Genet., 9, e1003377.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.5.1.98 additional information generation of homozygous Hdac2-/- and heterozygous Hdac1-/+/Hdac2-/- isozyne HDAC2 knockout mutant oocytes, penotypes overview Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.98 N-acetyl-Lys16-histone H4 + H2O Mus musculus
-
 acetate + histone H4
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.98 Mus musculus P70288 isozyme HDAC2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.98 oocyte
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.98 N-acetyl-Lys16-histone H4 + H2O
-
 Mus musculus acetate + histone H4
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.1.98 HDAC2
-
 Mus musculus
3.5.1.98 histone deacetylase 2
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.5.1.98 malfunction depleting maternal isozyme HDAC2 results in hyperacetylation of H4K16, while normal deacetylation of other lysine residues of histone H3 or H4 is observed, and defective chromosome condensation and segregation during oocyte maturation occurs in a subpopulation of oocytes, leading to increased incidence of aneuploidy likely accounts for the observed sub-fertility of mice harboring Hdac2-defective oocytes. The infertility of mice harboring Hdac1-/+/Hdac2-/- oocytes is attributed to failure of those few eggs that properly mature to metaphase II to initiate DNA replication following fertilization. Hdac1-/+/Hdac2-/- eggs are fertilized but fail to initiate DNA replication. The increased amount of acetylated H4K16 likely impairs kinetochore function in oocytes lacking isozyme HDAC2 because kinetochores in mutant oocytes are less able to form coldstable microtubule attachments and less CENP-A is located at the centromere. Phenotype, overview Mus musculus
3.5.1.98 physiological function histone deacetylase 2 regulates chromosome segregation and kinetochore function via H4K16 deacetylation during oocyte maturation in mouse. HDAC2 is the major isozyme that regulates global histone acetylation during oocyte development and is largely responsible for the deacetylation of H4K16 during maturation. Histone deacetylation that occurs during oocyte maturation is critical for proper chromosome segregation Mus musculus