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Literature summary extracted from

  • Moreau, M.; Westlake, T.; Zampogna, G.; Popescu, G.; Tian, M.; Noutsos, C.; Popescu, S.
    The Arabidopsis oligopeptidases TOP1 and TOP2 are salicylic acid targets that modulate SA-mediated signaling and the immune response (2013), Plant J., 76, 603-614.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.70 salicylate interacts with the isozyme and inhibits its peptidase activity to various degrees both in vitro and in plant extracts; interacts with the isozyme and inhibits its peptidase activity to various degrees both in vitro and in plant extracts. Specific isozyme TOP2–salicylate interaction may be dependent on plant-specific modifications of isozyme TOP2 Arabidopsis thaliana

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.70 chloroplast
-
 Arabidopsis thaliana 9507
-
3.4.24.70 cytosol
-
 Arabidopsis thaliana 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.70 Zn2+ a zinc-dependent metallopeptidase Arabidopsis thaliana

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.70 Arabidopsis thaliana Q949P2 isozyme TOP2
-
3.4.24.70 Arabidopsis thaliana Q94AM1 isozyme TOP1
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.70 leaf
-
 Arabidopsis thaliana
-

Synonyms

EC Number Synonyms Comment Organism
3.4.24.70 Top1
-
 Arabidopsis thaliana
3.4.24.70 Top2
-
 Arabidopsis thaliana

Expression

EC Number Organism Comment Expression
3.4.24.70 Arabidopsis thaliana expression of isozyme TOP2 is augmented by the flagellin peptide flg22 in an isozyme TOP1-dependent manner up

General Information

EC Number General Information Comment Organism
3.4.24.70 evolution the TOP isozymes contain the conserved His-Glu-XX-His (HEXXH) sequence of active-site residues and belong to the M3 family of metallopeptidases. TOP1 and TOP2 are located on opposite ends of chromosome 5 and share high homology, indicating the occurrence of a past intra-chromosomal duplication event Arabidopsis thaliana
3.4.24.70 malfunction plants with defective enzyme expression exhibit heightened resistance to exogenous salicylate treatment Arabidopsis thaliana
3.4.24.70 metabolism isozymes TOP1 and TOP2 are necessary for effector-triggered plant immunity via RPS2 and RPS4 resistance genes, and regulation of pathogen-triggered programmed cell death. TOP1 and TOP2 expression are coordinately regulated during pathogen-associated molecular pattern-triggered plant immunity Arabidopsis thaliana
3.4.24.70 physiological function the enzyme is a target for salicylic acid binding and participate in SA-mediated plant innate immunity. Both isozymes TOP1 and TOP2 seem to play a role in salicylic acid-dependent innate immunity, they are necessary for the immune response to avirulent pathogens. Isozyme TOP1 induces the augmentation of expression of isozyme TOP2 by the flagellin peptide flg22. Isozymes TOP1 and TOP2 are necessary for effector-triggered plant immunity via RPS2 and RPS4 resistance genes, and regulation of pathogen-triggered programmed cell death Arabidopsis thaliana
3.4.24.70 physiological function the enzyme is a target for salicylic acid binding and participate in SA-mediated plant innate immunity. Both isozymes TOP1 and TOP2 seem to play a role in salicylic acid-dependent innate immunity, they are necessary for the immune response to avirulent pathogens. Isozymes TOP1 and TOP2 are necessary for effector-triggered plant immunity via RPS2 and RPS4 resistance genes, and regulation of pathogen-triggered programmed cell death Arabidopsis thaliana