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Literature summary extracted from

  • Shimizu, S.; Kawashima, H.; Akimoto, K.; Shinmen, Y.; Sugano, H.; Yamada, H.
    Inhibition of DELTA5-desaturase in polyunsaturated fatty acid biosynthesis by (-)-asarinin and (-)-epiasarinin (1992), Phytochemistry, 31, 757-760.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.30 (+)-episesamin specific inhibitor Rattus norvegicus
1.14.19.30 (+)-sesamin specific inhibitor Rattus norvegicus
1.14.19.30 (+)-sesaminol specific inhibitor Rattus norvegicus
1.14.19.30 (+)-sesamolin specific inhibitor Rattus norvegicus
1.14.19.30 (-)-asarinin non-competitive inhibitor Rattus norvegicus
1.14.19.30 (-)-epiasarinin non-competitive inhibitor Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.30 microsome
-
 Rattus norvegicus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.30 dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+ Rattus norvegicus
-
 arachidonic acid + ferricytochrome b5 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.30 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.30 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.30 dihomo-gamma-linolenic acid + ferrocytochrome b5 + O2 + H+
-
 Rattus norvegicus arachidonic acid + ferricytochrome b5 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.30 DELTA5-desaturase
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.30 cytochrome b5
-
 Rattus norvegicus

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.14.19.30 0.28
-
 (-)-asarinin pH and temperature not specified in the publication Rattus norvegicus
1.14.19.30 0.71
-
 (-)-epiasarinin pH and temperature not specified in the publication Rattus norvegicus