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Literature summary extracted from

  • Roberts, R.L.; Wallace, M.C.; Drake, J.M.; Stamp, L.K.
    Identification of a novel thiopurine S-methyltransferase allele (TPMT 37) (2014), Pharmacogenet. Genomics, 24, 320-323.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.1.1.67 A719G the mutant exhibits reduced activity compared to the wild type enzyme Homo sapiens
2.1.1.67 C216T the mutant exhibits reduced activity compared to the wild type enzyme Homo sapiens
2.1.1.67 G238C the mutant exhibits reduced activity compared to the wild type enzyme Homo sapiens
2.1.1.67 G460A the mutant exhibits reduced activity compared to the wild type enzyme Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + a thiopurine Homo sapiens
-
S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.67 Homo sapiens P51580
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.1.1.67 erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.67 S-adenosyl-L-methionine + 6-mercaptopurine
-
Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine
-
?
2.1.1.67 S-adenosyl-L-methionine + a thiopurine
-
Homo sapiens S-adenosyl-L-homocysteine + a thiopurine S-methylether
-
?
2.1.1.67 S-adenosyl-L-methionine + azathioprine
-
Homo sapiens S-adenosyl-L-homocysteine + 6-methylmercaptopurine + ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.67 TPMT
-
Homo sapiens