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Literature summary extracted from

  • Gopinath, K.; Venclovas, A.; Ioerger, T.; Sacchettini, J.; McKinney, J.; Mizrahi, V.; Warner, D.
    A vitamin B12 transporter in Mycobacterium tuberculosis (2013), Open Biology, 3, 120175.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.6.2.8 membrane
-
 Mycobacterium tuberculosis 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.6.2.8 ATP + H2O + vitamin B12/out Mycobacterium tuberculosis
-
 ADP + phosphate + vitamin B12/in
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
7.6.2.8 Mycobacterium tuberculosis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.6.2.8 ATP + H2O + vitamin B12/out
-
 Mycobacterium tuberculosis ADP + phosphate + vitamin B12/in
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.6.2.8 BtuCD
-
 Mycobacterium tuberculosis
7.6.2.8 Rv1819c
-
 Mycobacterium tuberculosis
7.6.2.8 vitamin B12 transporter
-
 Mycobacterium tuberculosis

General Information

EC Number General Information Comment Organism
7.6.2.8 malfunction gene disruption eliminates the ability of Mycobacterium tuberculosis to use exogenous vitamin B12 in vitro Mycobacterium tuberculosis
7.6.2.8 physiological function the enzyme is required for the assimilation of exogenous vitamin B12 to enable methylmalonyl-CoA pathway function and is essential for corrinoid transport Mycobacterium tuberculosis