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Literature summary extracted from
- APOBEC3G cytosine deamination hotspots are defined by both sequence context and single-stranded DNA secondary structure (2013), Nucleic Acids Res., 41, 6139-6148.
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.B9 | cytosine in single-stranded viral DNA + H2O | Homo sapiens | - |
uracil in single-stranded viral DNA + NH3 | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.4.B9 | Homo sapiens | Q9HC16 | - |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.B9 | cytosine in single-stranded viral DNA + H2O | - |
Homo sapiens | uracil in single-stranded viral DNA + NH3 | - |
? | |
| 3.5.4.B9 | additional information | the enzyme cannot readily deaminate a cytosine dinucleotide in single-stranded DNA stem structures or in nucleotide base loops composed of three bases. Single-stranded nucleotide loops up to seven bases in length are poor targets for enzyme activity unless cytosine residues flank the cytosine dinucleotide. The enzyme favors adenines, cytosines and thymines flanking the cytosine dinucleotide target in unstructured regions of single-stranded DNA. Low cytosine deaminase activity is detected when guanines flank the cytosine dinucleotide | Homo sapiens | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.5.4.B9 | A3G | - |
Homo sapiens |
| 3.5.4.B9 | APOBEC3G | - |
Homo sapiens |
| 3.5.4.B9 | apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3G | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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