EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.213 | cytidine | substrate inhibition | Thermococcus kodakarensis |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.212 | 0.53 | - |
alpha-D-ribose 1-phosphate | presence of Mg2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 0.53 | - |
alpha-D-ribose-1-phosphate | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 4.19 | 8.37 | ADP | depending on the presence of Ca2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 4.2 | - |
ADP | presence of Ca2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 7.3 | - |
ADP | presence of Mg2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 7.3 | - |
ADP | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 12 | - |
2-deoxy-alpha-D-ribose 1-phosphate | presence of Mg2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 12 | - |
2-deoxy-alpha-D-ribose-1-phosphate | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 19 | - |
GDP | presence of Mg2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 19 | - |
GDP | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.213 | 1.71 | - |
cytidine | pH and temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.213 | 4.11 | - |
3'-deoxycytidine | pH and temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.213 | 5.72 | - |
ATP | pH and temperature not specified in the publication | Thermococcus kodakarensis |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.212 | Ca2+ | divalent cation required, Mg2+ and Ca2+ are the most preferred. 107% of the activtiy with Mg2+ | Thermococcus kodakarensis | |
2.7.1.212 | Co2+ | 59% of the activtiy with Mg2+ | Thermococcus kodakarensis | |
2.7.1.212 | Mg2+ | divalent cation required, Mg2+ and Ca2+ are the most preferred | Thermococcus kodakarensis | |
2.7.1.212 | additional information | activities with Mn2+, Ni2+, Zn2+ and Cu2+ are all less than 20% of that with Mg2+ | Thermococcus kodakarensis | |
2.7.1.213 | Co2+ | 26% activity compared to Mg2+ | Thermococcus kodakarensis | |
2.7.1.213 | KCl | 300 mM, 3.6fold increase of activity | Thermococcus kodakarensis | |
2.7.1.213 | Mg2+ | most preferred divalent metal ion | Thermococcus kodakarensis | |
2.7.1.213 | Mn2+ | 68% activity compared to Mg2+ | Thermococcus kodakarensis | |
2.7.1.213 | additional information | ca2+, Ni2+, Zn2+, cu2+ show less than 20% avtivation | Thermococcus kodakarensis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.212 | ADP + alpha-D-ribose-1-phosphate | Thermococcus kodakarensis | - |
AMP + alpha-D-ribose 1,5-bisphosphate | - |
? | |
2.7.1.212 | alpha-D-ribose 1-phosphate + ADP | Thermococcus kodakarensis | - |
alpha-D-ribose 1,5-bisphosphate + AMP | - |
ir | |
2.7.1.213 | cytidine + ATP | Thermococcus kodakarensis | - |
CMP + ADP | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.212 | Thermococcus kodakarensis | Q5JDG9 | - |
- |
2.7.1.213 | Thermococcus kodakarensis | Q5JEK6 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.212 | 2-deoxy-alpha-D-ribose 1-phosphate + ADP | - |
Thermococcus kodakarensis | 2-deoxy-alpha-D-ribose 1,5-bisphosphate + AMP | - |
ir | |
2.7.1.212 | ADP + 2-deoxy-alpha-D-ribose-1-phosphate | - |
Thermococcus kodakarensis | AMP + 2-deoxy-alpha-D-ribose 1,5-bisphosphate | - |
? | |
2.7.1.212 | ADP + alpha-D-ribose-1-phosphate | - |
Thermococcus kodakarensis | AMP + alpha-D-ribose 1,5-bisphosphate | - |
? | |
2.7.1.212 | alpha-D-ribose 1-phosphate + ADP | - |
Thermococcus kodakarensis | alpha-D-ribose 1,5-bisphosphate + AMP | - |
ir | |
2.7.1.212 | alpha-D-ribose 1-phosphate + ADP | irreversible under physiological conditions | Thermococcus kodakarensis | alpha-D-ribose 1,5-bisphosphate + AMP | irreversible under physiological conditions | ir | |
2.7.1.212 | alpha-D-ribose 1-phosphate + GDP | irreversible under physiological conditions | Thermococcus kodakarensis | alpha-D-ribose 1,5-bisphosphate + GMP | - |
ir | |
2.7.1.212 | GDP + alpha-D-ribose-1-phosphate | 56% of the activity with ADP | Thermococcus kodakarensis | GMP + alpha-D-ribose 1,5-bisphosphate | - |
? | |
2.7.1.212 | additional information | no substrates: CDP, diphosphate | Thermococcus kodakarensis | ? | - |
? | |
2.7.1.212 | UDP + alpha-D-ribose-1-phosphate | 9% of the activity with ADP | Thermococcus kodakarensis | UMP + alpha-D-ribose 1,5-bisphosphate | - |
? | |
2.7.1.213 | 3'-deoxycytidine + ATP | - |
Thermococcus kodakarensis | 3'-dCMP + ADP | - |
? | |
2.7.1.213 | cytidine + ATP | - |
Thermococcus kodakarensis | CMP + ADP | - |
? | |
2.7.1.213 | cytidine + CTP | 30% activity with CTP compared to ATP | Thermococcus kodakarensis | CMP + CDP | - |
? | |
2.7.1.213 | cytidine + GTP | 70% activity with GTP compared to ATP | Thermococcus kodakarensis | CMP + GDP | - |
? | |
2.7.1.213 | cytidine + UTP | 30% activity with UTP compared to ATP | Thermococcus kodakarensis | CMP + UDP | - |
? | |
2.7.1.213 | uridine + ATP | - |
Thermococcus kodakarensis | UMP + ADP | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.212 | ADP-dependent ribose-1-phosphate kinase | - |
Thermococcus kodakarensis |
2.7.1.212 | TK2029 | - |
Thermococcus kodakarensis |
2.7.1.212 | TK2029 | locus name | Thermococcus kodakarensis |
2.7.1.213 | TK1843 | locus name | Thermococcus kodakarensis |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.1.212 | 85 | - |
- |
Thermococcus kodakarensis |
2.7.1.213 | 90 | - |
- |
Thermococcus kodakarensis |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.212 | 73 | - |
2-deoxy-alpha-D-ribose 1-phosphate | presence of Mg2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 73 | - |
2-deoxy-alpha-D-ribose-1-phosphate | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 189 | - |
GDP | presence of Mg2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 189 | - |
GDP | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 485 | - |
alpha-D-ribose 1-phosphate | presence of Mg2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 485 | - |
alpha-D-ribose-1-phosphate | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 612 | - |
ADP | presence of Mg2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 612 | - |
ADP | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 856 | 1160 | ADP | depending on the presence of Ca2+, pH and temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 856 | - |
ADP | presence of Ca2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.213 | 222 | - |
ATP | pH and temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.213 | 226 | - |
3'-deoxycytidine | pH and temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.213 | 280 | - |
cytidine | pH and temperature not specified in the publication | Thermococcus kodakarensis |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
2.7.1.212 | 5 | 8 | - |
Thermococcus kodakarensis |
2.7.1.213 | 5 | 9 | - |
Thermococcus kodakarensis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.213 | 29.3 | - |
cytidine | pH and temperature not specified in the publication | Thermococcus kodakarensis |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.212 | 6.3 | - |
2-deoxy-alpha-D-ribose-1-phosphate | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 10.2 | - |
GDP | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 83.6 | - |
ADP | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 204 | - |
ADP | presence of Ca2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.212 | 915 | - |
alpha-D-ribose-1-phosphate | presence of Mg2+, pH not specified in the publication, temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.213 | 38.8 | - |
ATP | pH and temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.213 | 55 | - |
3'-deoxycytidine | pH and temperature not specified in the publication | Thermococcus kodakarensis | |
2.7.1.213 | 164 | - |
cytidine | pH and temperature not specified in the publication | Thermococcus kodakarensis |