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Literature summary extracted from

  • Taga, M.E.; Miller, S.T.; Bassler, B.L.
    Lsr-mediated transport and processing of AI-2 in Salmonella typhimurium (2003), Mol. Microbiol., 50, 1411-1427.
    View publication on PubMed

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.189 additional information construction of an in frame deletion of the lsrK gene, phenotype, overview Salmonella enterica subsp. enterica serovar Typhimurium

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.189 cytoplasm
-
 Salmonella enterica subsp. enterica serovar Typhimurium 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.189 Mg2+ required Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.189 ATP + autoinducer-2 Salmonella enterica subsp. enterica serovar Typhimurium i.e. AI-2 ADP + phosphorylated autoinducer-2
-
 ?
2.7.1.189 ATP + autoinducer-2 Salmonella enterica subsp. enterica serovar Typhimurium MET235 i.e. AI-2 ADP + phosphorylated autoinducer-2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.189 Salmonella enterica subsp. enterica serovar Typhimurium
-
 gene lsrK
-
2.7.1.189 Salmonella enterica subsp. enterica serovar Typhimurium MET235
-
 gene lsrK
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.189 ATP + autoinducer-2 i.e. AI-2 Salmonella enterica subsp. enterica serovar Typhimurium ADP + phosphorylated autoinducer-2
-
 ?
2.7.1.189 ATP + autoinducer-2 i.e. AI-2 Salmonella enterica subsp. enterica serovar Typhimurium MET235 ADP + phosphorylated autoinducer-2
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.189 lsrK
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.189 ATP
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Expression

EC Number Organism Comment Expression
2.7.1.189 Salmonella enterica subsp. enterica serovar Typhimurium transcription of lsrK is not regulated by luxS or AI-2 additional information

General Information

EC Number General Information Comment Organism
2.7.1.189 malfunction in the DELTAlsrK deletion mutant, expression of the lsr-lacZ fusion is not induced by the presence of luxS or by exogenously supplied AI-2 in contrast to the wild-type. The enzyme activity and ATPase activity in the presence of culture fluids prepared from a luxS null strain is consistently lower than the background level Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.189 metabolism Lsr-mediated transport and processing of autoinducer 2, AI-2, overview Salmonella enterica subsp. enterica serovar Typhimurium
2.7.1.189 physiological function LsrK is required for the regulation of the lsr operon and the AI-2 uptake process. LsrK is a kinase that phosphorylates AI-2 upon entry into the cell, phosphorylation of AI-2 results in its sequestration in the cytoplasm Salmonella enterica subsp. enterica serovar Typhimurium