Literature summary extracted from
Gunn, J.S.; Lim, K.B.; Krueger, J.; Kim, K.; Guo, L.; Hackett, M.; Miller, S.I.
PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance (1998), Mol. Microbiol., 27, 1171-1182.
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
2.7.8.43 |
additional information |
JSG435 carries a mutant pmrA locus allele (pmrA505), JSG435 is mutagenized with the transposon Tn10d. Chromosomal mapping of the transposon insertions of the two polymyxin B sensitive strains shows them to be located at 50-52 centisomes (JSG485) and 43-45 centisomes (JSG486), thus eliminating the possibility that mutations in these regulatory loci are responsible for the observed phenotypic change |
Salmonella enterica |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
2.7.8.43 |
Salmonella enterica |
Q8Z1P4 |
serovar Typhimurium, gene pmrA |
- |
2.7.8.43 |
Salmonella enterica 14028s |
Q8Z1P4 |
serovar Typhimurium, gene pmrA |
- |
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
2.7.8.43 |
PmrA |
- |
Salmonella enterica |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
2.7.8.43 |
malfunction |
JSG435 carries a mutant pmrA locus allele (pmrA505) that results in high level polymyxin resistance, probably due to constitutive expression of PmrA/PmrB-activated genes |
Salmonella enterica |
2.7.8.43 |
metabolism |
two unlinked PmrA/PmrB-regulated loci, designated pmrE and pmrF, are identified as necessary for resistance of the organism to polymyxin B and for the addition of aminoarabinose to lipid A. Genes immediately flanking this putative operon are also regulated by PmrA/PmrB and/or have been associated with Salmonella typhimurium polymyxin resistance |
Salmonella enterica |