Literature summary extracted from

Kim, J.D.; Kim, E.; Koun, S.; Ham, H.J.; Rhee, M.; Kim, M.J.; Huh, T.L.
Proper activity of histone H3 lysine 4 (H3K4) methyltransferase is required for morphogenesis during zebrafish cardiogenesis (2015), Mol. Cells, 38, 580-586.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.1.1.354	Danio rerio	Q6DHG0	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.1.1.354	heart	high expression within developing heart	Danio rerio	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.1.1.354	SetD7	-	Danio rerio
2.1.1.354	Smyd3	-	Danio rerio

General Information

EC Number	General Information	Comment	Organism
2.1.1.354	physiological function	knock-down of either histone H3 lysine methyltransferase Smyd3 or SetD7 genes leads to severe defects in cardiac morphogenesis without altering the expression pattern of heart markers, including cmlc2, vmhc, and amhc. Double knock-down of both Smyd3 and SetD7 causes synergistic defects in heart development. Overexpression of these genes also causes the heart morphogenesis defect in zebrafish	Danio rerio

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Release 2023.1 (January 2023)