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Literature summary extracted from
- DELTA5 Desaturase activity in rat kidney microsomes (1993), Mol. Cell. Biochem., 129, 31-37.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.30 | (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] | the DELTA5 desaturase activity in kidney microsomes increases linearly with the substrate concentration up to 0.02 mM | Rattus norvegicus |  |
| 1.14.19.30 | additional information | neither the cytosolic renal fraction nor the cytosolic liver fraction enhance the DELTA5 desaturase activity | Rattus norvegicus |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.19.30 | 0.056 | - |
(8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] | at pH 7.0 and 36°C | Rattus norvegicus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.14.19.30 | microsome | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.19.30 | (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ | Rattus norvegicus | - |
(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.19.30 | Rattus norvegicus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.14.19.30 | kidney | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.19.30 | (8Z,11Z,14Z)-icosa-8,11,14-trienoyl-[glycerolipid] + ferrocytochrome b5 + O2 + H+ | - |
Rattus norvegicus | (5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-tetraenoyl-[glycerolipid] + ferricytochrome b5 + H2O | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.19.30 | DELTA5 desaturase | - |
Rattus norvegicus |
| 1.14.19.30 | DES5 | - |
Rattus norvegicus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.19.30 | 7 | - |
- |
Rattus norvegicus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.19.30 | ATP | dependent on | Rattus norvegicus | |
| 1.14.19.30 | CoA | dependent on | Rattus norvegicus | |
| 1.14.19.30 | cytochrome b5 | dependent on | Rattus norvegicus | |
| 1.14.19.30 | NADH | dependent on | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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