EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
3.4.24.56 | cytoplasm | - |
Drosophila melanogaster | 5737 | - |
3.4.24.56 | plasma membrane | - |
Drosophila melanogaster | 5886 | - |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.56 | Drosophila melanogaster | P22817 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.24.56 | adult | highest expression in male adults | Drosophila melanogaster | - |
3.4.24.56 | body wall | - |
Drosophila melanogaster | - |
3.4.24.56 | brain | - |
Drosophila melanogaster | - |
3.4.24.56 | fat body | highest expression | Drosophila melanogaster | - |
3.4.24.56 | gut | - |
Drosophila melanogaster | - |
3.4.24.56 | imaginal disc | - |
Drosophila melanogaster | - |
3.4.24.56 | larva | - |
Drosophila melanogaster | - |
3.4.24.56 | pupa | - |
Drosophila melanogaster | - |
3.4.24.56 | salivary gland | - |
Drosophila melanogaster | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.4.24.56 | IDE | - |
Drosophila melanogaster |
3.4.24.56 | Insulin-degrading enzyme | - |
Drosophila melanogaster |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.4.24.56 | malfunction | loss of enzyme function favors insulin resistance, a hallmark of diabetes mellitus type II. Down-regulation of the enzyme provokes reduction of tissue growth and sensitizes developmental timing and metabolism to high-sucrose diets | Drosophila melanogaster |
3.4.24.56 | metabolism | the enzyme can modulate Drosophila insulin-like peptide 2 levels, thereby restricting activation of the phosphatidylinositol-3-phosphate kinase pathway and promoting activation of Drosophila forkhead box, subgroup O transcription factor | Drosophila melanogaster |
3.4.24.56 | physiological function | the enzyme provokes growth reduction mediated by the phosphatidylinositol-3-phosphate kinase pathway in a cell-autonomous manner | Drosophila melanogaster |