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Literature summary extracted from

  • Galagovsky, D.; Katz, M.; Acevedo, J.; Sorianello, E.; Glavic, A.; Wappner, P.
    The Drosophila insulin-degrading enzyme restricts growth by modulating the PI3K pathway in a cell-autonomous manner (2014), Mol. Biol. Cell, 25, 916-924.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.56 cytoplasm
-
 Drosophila melanogaster 5737
-
3.4.24.56 plasma membrane
-
 Drosophila melanogaster 5886
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Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Drosophila melanogaster P22817
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.56 adult highest expression in male adults Drosophila melanogaster
-
3.4.24.56 body wall
-
 Drosophila melanogaster
-
3.4.24.56 brain
-
 Drosophila melanogaster
-
3.4.24.56 fat body highest expression Drosophila melanogaster
-
3.4.24.56 gut
-
 Drosophila melanogaster
-
3.4.24.56 imaginal disc
-
 Drosophila melanogaster
-
3.4.24.56 larva
-
 Drosophila melanogaster
-
3.4.24.56 pupa
-
 Drosophila melanogaster
-
3.4.24.56 salivary gland
-
 Drosophila melanogaster
-

Synonyms

EC Number Synonyms Comment Organism
3.4.24.56 IDE
-
 Drosophila melanogaster
3.4.24.56 Insulin-degrading enzyme
-
 Drosophila melanogaster

General Information

EC Number General Information Comment Organism
3.4.24.56 malfunction loss of enzyme function favors insulin resistance, a hallmark of diabetes mellitus type II. Down-regulation of the enzyme provokes reduction of tissue growth and sensitizes developmental timing and metabolism to high-sucrose diets Drosophila melanogaster
3.4.24.56 metabolism the enzyme can modulate Drosophila insulin-like peptide 2 levels, thereby restricting activation of the phosphatidylinositol-3-phosphate kinase pathway and promoting activation of Drosophila forkhead box, subgroup O transcription factor Drosophila melanogaster
3.4.24.56 physiological function the enzyme provokes growth reduction mediated by the phosphatidylinositol-3-phosphate kinase pathway in a cell-autonomous manner Drosophila melanogaster