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Literature summary extracted from

  • Tyc, J.; Klingbeil, M.M.; Lukes, J.
    Mitochondrial heat shock protein machinery hsp70/hsp40 is indispensable for proper mitochondrial DNA maintenance and replication (2015), mBio, 6, e02425-14.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
3.6.4.10 additional information RNAi-mediated downregulation of mtHsp40, Cells depleted for mtHsp70/mtHsp40 machinery lose kDNA but does not disrupt the cell cycle, phenotype Trypanosoma brucei
3.6.4.10 additional information RNAi-mediated downregulation of mtHsp70, cells depleted for mtHsp70/mtHsp40 machinery lose kDNA but does not disrupt the cell cycle, phenotype Trypanosoma brucei

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.4.10 mitochondrion the chaperones mtHsp70 and mtHsp40 and their cofactor Mge1 are uniformly distributed throughout the single mitochondrial network Trypanosoma brucei 5739
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.4.10 Mg2+ required Trypanosoma brucei

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.4.10 ATP + H2O Trypanosoma brucei
-
 ADP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.4.10 Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.4.10 ATP + H2O
-
 Trypanosoma brucei ADP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.4.10 mitochondrial heat shock protein 40
-
 Trypanosoma brucei
3.6.4.10 mitochondrial heat shock protein 70
-
 Trypanosoma brucei
3.6.4.10 mtHsp40
-
 Trypanosoma brucei
3.6.4.10 mtHSP70
-
 Trypanosoma brucei

General Information

EC Number General Information Comment Organism
3.6.4.10 malfunction depletion of mtHsp40 leads tokDNA loss Trypanosoma brucei
3.6.4.10 malfunction depletion of mtHsp70 leads tokDNA loss Trypanosoma brucei
3.6.4.10 physiological function the highly conserved mitochondrial chaperone machinery, essential for proper functioning of mitochondria, is composed of mitochondrial heat shock proteins 70 and 40 (mtHsp70/mtHsp40) and the ATP exchange factor Mge1. The chaperones are indispensable for the maintenance and replication of kDNA, in addition to their already known functions in Fe-S cluster synthesis and protein import Trypanosoma brucei