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Literature summary extracted from

  • Ghebremariam, Y.T.; Erlanson, D.A.; Cooke, J.P.
    A novel and potent inhibitor of dimethylarginine dimethylaminohydrolase: a modulator of cardiovascular nitric oxide (2014), J. Pharmacol. Exp. Ther., 348, 69-76.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.3.18 l-257
-
 Homo sapiens
3.5.3.18 PD 404182 i.e. 6H-6-imino-(2,3,4,5-tetrahydropyrimido)[1,2-c]-[1,3]benzothiazine, potent active-site competitive inhibitor, about 75% inhibition at 0.05 mM Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.3.18 Nomega,Nomega'-dimethyl-L-arginine + H2O Homo sapiens
-
 dimethylamine + L-citrulline
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.18 Homo sapiens O94760
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.18 Nomega,Nomega'-dimethyl-L-arginine + H2O
-
 Homo sapiens dimethylamine + L-citrulline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.3.18 DDAH1
-
 Homo sapiens
3.5.3.18 dimethylarginine dimethylaminohydrolase isoform 1
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.3.18 0.009
-
 at 37°C, pH not specified in the publication Homo sapiens PD 404182