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Literature summary extracted from

  • Gaublomme, D.; Buyens, T.; De Groef, L.; Stakenborg, M.; Janssens, E.; Ingvarsen, S.; Porse, A.; Behrendt, N.; Moons, L.
    Matrix metalloproteinase 2 and membrane type 1 matrix metalloproteinase co-regulate axonal outgrowth of mouse retinal ganglion cells (2014), J. Neurochem., 129, 966-979.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.80 DX-2400 enzyme activity is inhibited with 65.8 nM or 658 nM of the enzyme function-blocking antibody DX-2400 Mus musculus
3.4.24.80 GM6001
-
 Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.80 pro-MMP-2 + H2O Mus musculus
-
 MMP-2 + MMP-2 propeptide
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.80 Mus musculus P53690
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.80 glial cell
-
 Mus musculus
-
3.4.24.80 retinal ganglion cell
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.80 Gelatin + H2O
-
 Mus musculus ?
-
 ?
3.4.24.80 pro-MMP-2 + H2O
-
 Mus musculus MMP-2 + MMP-2 propeptide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.80 membrane type 1 matrix metalloproteinase
-
 Mus musculus
3.4.24.80 MT1-MMP
-
 Mus musculus

General Information

EC Number General Information Comment Organism
3.4.24.80 physiological function membrane type 1 matrix metalloproteinase-dependent activation of MMP-2 is required for optimal neurite outgrowth Mus musculus