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Literature summary extracted from

  • Kwon, Y.J.; Sohn, M.J.; Kim, C.J.; Koshino, H.; Kim, W.G.
    Flavimycins A and B, dimeric 1,3-dihydroisobenzofurans with peptide deformylase inhibitory activity from Aspergillus flavipes (2012), J. Nat. Prod., 75, 271-274.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.88 flavimycin A a dimeric 1,3-dihydroisobenzofuran, isolated from cultures of Aspergillus flavipes, structure analysis by NMR and mass spectrometry, the inhibitor exists as epimeric mixture at C-1 through fast hemiacetal-aldehyde tautomerism. The compound has antibacterial activity against Staphylococcus aureus including MRSA, with MIC values of 0.032-0.064 mg/mL Staphylococcus aureus
3.5.1.88 flavimycin B a dimeric 1,3-dihydroisobenzofuran, isolated from cultures of Aspergillus flavipes, structure analysis by NMR and mass spectrometry, the inhibitor exists as epimeric mixture at C-1 through fast hemiacetal-aldehyde tautomerism. The compound has antibacterial activity against Staphylococcus aureus including MRSA, with MIC values of 0.032-0.064 mg/mL Staphylococcus aureus

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.88 Staphylococcus aureus
-
-
-

Synonyms

EC Number Synonyms Comment Organism
3.5.1.88 PDF
-
 Staphylococcus aureus

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.88 0.0358
-
 pH and temperature not specified in the publication Staphylococcus aureus flavimycin A
3.5.1.88 0.1001
-
 pH and temperature not specified in the publication Staphylococcus aureus flavimycin B