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Literature summary extracted from
- Inhibition of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA1) by rutin derivatives (2015), J. Muscle Res. Cell Motil., 36, 183-194.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.2.2.10 | rutin | - |
Oryctolagus cuniculus |  |
| 7.2.2.10 | rutin 4'''-O-arachidonate | - |
Oryctolagus cuniculus | |
| 7.2.2.10 | rutin 4'''-O-erucate | - |
Oryctolagus cuniculus | |
| 7.2.2.10 | rutin 4'''-O-linoleate | - |
Oryctolagus cuniculus | |
| 7.2.2.10 | rutin 4'''-O-linolenate | - |
Oryctolagus cuniculus | |
| 7.2.2.10 | rutin 4'''-O-oleate | - |
Oryctolagus cuniculus | |
| 7.2.2.10 | rutin 4'''-O-stearate | - |
Oryctolagus cuniculus | |
| 7.2.2.10 | rutin palmitate | - |
Oryctolagus cuniculus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.2.2.10 | endoplasmic reticulum | - |
Oryctolagus cuniculus | 5783 | - |
| 7.2.2.10 | sarcoplasmic reticulum | - |
Oryctolagus cuniculus | 16529 | - |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.10 | ATP + H2O + Ca2+[side 1] | Oryctolagus cuniculus | - |
ADP + phosphate + Ca2+[side 2] | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.2.2.10 | Oryctolagus cuniculus | P04191 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 7.2.2.10 | skeletal muscle | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.2.2.10 | ATP + H2O + Ca2+[side 1] | - |
Oryctolagus cuniculus | ADP + phosphate + Ca2+[side 2] | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.2.2.10 | sarcoplasmic reticulum calcium-dependent adenosine triphosphatase | - |
Oryctolagus cuniculus |
| 7.2.2.10 | sarcoplasmic/endoplasmic reticulum Ca2+-ATPase | - |
Oryctolagus cuniculus |
| 7.2.2.10 | SERCA1 | - |
Oryctolagus cuniculus |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 7.2.2.10 | 0.023 | - |
at 37°C and pH 7.4 | Oryctolagus cuniculus | rutin 4'''-O-arachidonate | |
| 7.2.2.10 | 0.025 | - |
at 37°C and pH 7.4 | Oryctolagus cuniculus | rutin 4'''-O-linoleate | |
| 7.2.2.10 | 0.035 | - |
at 37°C and pH 7.4 | Oryctolagus cuniculus | rutin 4'''-O-stearate | |
| 7.2.2.10 | 0.05 | - |
at 37°C and pH 7.4 | Oryctolagus cuniculus | rutin 4'''-O-oleate | |
| 7.2.2.10 | 0.05 | - |
at 37°C and pH 7.4 | Oryctolagus cuniculus | rutin 4'''-O-erucate | |
| 7.2.2.10 | 0.062 | - |
at 37°C and pH 7.4 | Oryctolagus cuniculus | rutin 4'''-O-linolenate | |
| 7.2.2.10 | 0.064 | - |
at 37°C and pH 7.4 | Oryctolagus cuniculus | rutin palmitate | |
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Release 2023.1 (January 2023)
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