EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.2 | 1,13-bis[4'-(4H-chromen-4-on-2-yl)phenyl]-N-(benzyl)-1,4,10,13-tetraoxa-7-azatridecane | stimulates ATPase activity by 2.7-fold | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
7.6.2.2 | 1,13-bis[4'-(4H-chromen-4-on-2-yl)phenyl]-N-(benzyl)-1,4,10,13-tetraoxa-7-azatridecane | competitive inhibitor to doxorubicin binding by P-glycoprotein | Homo sapiens | |
7.6.2.2 | apigenin | - |
Homo sapiens | |
7.6.2.2 | cyclosporine A | - |
Homo sapiens | |
7.6.2.2 | Ko143 | - |
Homo sapiens | |
7.6.2.2 | valspodar | - |
Homo sapiens | |
7.6.2.2 | verapamil | - |
Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
7.6.2.2 | Homo sapiens | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
7.6.2.2 | MDA435/LCC6MDR1 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
7.6.2.2 | ATP + H2O + 1,13-bis[4'-(4H-chromen-4-on-2-yl)phenyl]-N-(benzyl)-1,4,10,13-tetraoxa-7-azatridecane/in | - |
Homo sapiens | ADP + phosphate + 1,13-bis[4'-(4H-chromen-4-on-2-yl)phenyl]-N-(benzyl)-1,4,10,13-tetraoxa-7-azatridecane/out | - |
? | |
7.6.2.2 | ATP + H2O + doxorubicin/in | - |
Homo sapiens | ADP + phosphate + doxorubicin/out | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
7.6.2.2 | P-glycoprotein | - |
Homo sapiens |
7.6.2.2 | P-gp | - |
Homo sapiens |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
7.6.2.2 | 0.00028 | 0.00034 | 1,13-bis[4'-(4H-chromen-4-on-2-yl)phenyl]-N-(benzyl)-1,4,10,13-tetraoxa-7-azatridecane | at 37°C, pH not specified in the publication | Homo sapiens |