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Literature summary extracted from

  • Wang, X.; Li, Y.; Xie, K.; Yi, Q.; Chen, Q.; Wang, X.; Shen, H.; Xia, Q.; Zhao, P.
    Ca2+ and endoplasmic reticulum Ca2+-ATPase regulate the formation of silk fibers with favorable mechanical properties (2015), J. Insect Physiol., 73, 53-59.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.2.2.10 expressed in Escherichia coli BL21(DE3) cells Bombyx mori

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.2.2.10 thapsigargin
-
Bombyx mori

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.10 sarcoplasmic reticulum
-
Bombyx mori 16529
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
7.2.2.10 ATP + H2O + Ca2+[side 1] Bombyx mori
-
ADP + phosphate + Ca2+[side 2]
-
?

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.10 Bombyx mori
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.10 silk gland
-
Bombyx mori
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.2.2.10 ATP + H2O + Ca2+[side 1]
-
Bombyx mori ADP + phosphate + Ca2+[side 2]
-
?

Synonyms

EC Number Synonyms Comment Organism
7.2.2.10 sarcoplasmic reticulum Ca2+-ATPase
-
Bombyx mori
7.2.2.10 SERCA
-
Bombyx mori

General Information

EC Number General Information Comment Organism
7.2.2.10 malfunction after injection of thapsigargin to block enzyme activity, silkworms show a silk-spinning deficiency (30% of silkworms cannot spin normally and another 25% constructes abnormal cocoons) and their cocoons have higher calcium content compared to that of controls Bombyx mori
7.2.2.10 physiological function the enzyme has a key function in calcium transportation in anterior silk gland that is related to maintaining a suitable ionic environment. This ionic environment with a proper Ca2+ concentration is crucial for the formation of silk fibers with favorable mechanical performances Bombyx mori