EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.24.34 | Homo sapiens | P22894 | - |
- |
3.4.24.34 | Mus musculus | O70138 | - |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.4.24.34 | commercial preparation | - |
Homo sapiens | - |
3.4.24.34 | commercial preparation | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.24.34 | TNF-alpha + H2O | - |
Homo sapiens | ? | MMP8 exhibits TNF-alpha-converting enzyme activity by cleaving the prodomain of TNF-alpha at residues A74-Q75 and A76-V77 | ? |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.4.24.34 | physiological function | MMP-8 is upregulated in LPS-stimulated BV2 microglial cells and primary cultured microglia, and treatment with MMP-8 inhibitor or MMP-8 short hairpin RNA suppresses proinflammatory molecules, particularly TNF-alpha secretion. Treatment with MMP-8 inhibitor inhibits TNF-alpha-converting enzyme activity more efficiently than TAPI-0, a general TNF-alpha converting enzyme inhibitor. It inhibits MAPK phosphorylation, NF-kappaB/AP-1 activity, and reactive oxygen species production | Homo sapiens |
3.4.24.34 | physiological function | MMP-8 is upregulated in septic conditions, particularly in microglia. Administration of MMP-8 inhibitor or MMP-8 short hairpin RNA significantly inhibits microglial activation and expression/secretion of TNF-alpha in brain tissue, serum, and cerebrospinal fluid of lipopolysaccharid-induced septic mice | Mus musculus |