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Literature summary extracted from

  • Ndemangou, B.; Sielinou, V.T.; Vardamides, J.C.; Ali, M.S.; Lateef, M.; Iqbal, L.; Afza, N.; Nkengfack, A.E.
    Urease inhibitory isoflavonoids from different parts of Calopogonium mucunoides (Fabaceae) (2013), J. Enzyme Inhib. Med. Chem., 28, 1156-1161.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.5 2',4',5',7-tetramethoxyisoflavone
-
 Helicobacter pylori
3.5.1.5 4'-O-methylalpinumisoflavone
-
 Helicobacter pylori
3.5.1.5 4'-O-methylderrone
-
 Helicobacter pylori
3.5.1.5 6a,12a-dehydroxydegueline
-
 Helicobacter pylori
3.5.1.5 7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
-
 Helicobacter pylori
3.5.1.5 7-O-methylcuneantin
-
 Helicobacter pylori
3.5.1.5 alpinumisoflavone
-
 Helicobacter pylori
3.5.1.5 atalantoflavone
-
 Helicobacter pylori
3.5.1.5 Calopogonium isoflavone A
-
 Helicobacter pylori
3.5.1.5 additional information enzyme inhibition by flavonoids from tropicaal herb Calopogonium mucunoides,overview. No or poor inhibition by cabreuvin and 7-O-methylpseudobaptigenin Helicobacter pylori
3.5.1.5 Thiourea
-
 Helicobacter pylori

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.5 urea + H2O Helicobacter pylori
-
 CO2 + 2 NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.5 Helicobacter pylori
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.5 urea + H2O
-
 Helicobacter pylori CO2 + 2 NH3
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.5.1.5 30
-
 assay at Helicobacter pylori

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.5 8.2
-
 assay at Helicobacter pylori

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.5.1.5 0.0079
-
 pH 8.2, 30°C Helicobacter pylori 7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
3.5.1.5 0.0084
-
 pH 8.2, 30°C Helicobacter pylori 7-O-methylcuneantin
3.5.1.5 0.0111
-
 pH 8.2, 30°C Helicobacter pylori 6a,12a-dehydroxydegueline
3.5.1.5 0.012
-
 pH 8.2, 30°C Helicobacter pylori 4'-O-methylderrone
3.5.1.5 0.0126
-
 pH 8.2, 30°C Helicobacter pylori 2',4',5',7-tetramethoxyisoflavone
3.5.1.5 0.0173
-
 pH 8.2, 30°C Helicobacter pylori atalantoflavone
3.5.1.5 0.0216
-
 pH 8.2, 30°C Helicobacter pylori Thiourea
3.5.1.5 0.0254
-
 pH 8.2, 30°C Helicobacter pylori 4'-O-methylalpinumisoflavone
3.5.1.5 0.0944
-
 pH 8.2, 30°C Helicobacter pylori Calopogonium isoflavone A
3.5.1.5 0.232
-
 pH 8.2, 30°C Helicobacter pylori alpinumisoflavone