Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Jensen, D.; Halls, M.; Murphy, J.; Canals, M.; Cattaruzza, F.; Poole, D.; Lieu, T.; Koon, H.; Pothoulakis, C.; Bunnett, N.
    Endothelin-converting enzyme 1 and beta-arrestins exert spatiotemporal control of substance P-induced inflammatory signals (2014), J. Biol. Chem., 289, 20283-20294.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.71 expressed in NCM-460 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.71 SM-19712
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.71 endosome
-
 Homo sapiens 5768
-
3.4.24.71 membrane transmembrane protein Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.71 Substance P + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.71 Homo sapiens P42892
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.71 colonocyte
-
 Homo sapiens
-
3.4.24.71 HEK-293 cell
-
 Homo sapiens
-
3.4.24.71 NCM-460 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.71 Substance P + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.24.71 ECE-1
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
3.4.24.71 physiological function the primary function of ECE-1 in substance P-dependent inflammatory signaling is to promote resensitization, which allows the sustained neurokinin 1 receptor signaling from the plasma membrane that drives inflammation Homo sapiens