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Literature summary extracted from

  • Estrada, D.F.; Skinner, A.L.; Laurence, J.S.; Scott, E.E.
    Human cytochrome P450 17A1 conformational selection: modulation by ligand and cytochrome b5 (2014), J. Biol. Chem., 289, 14310-14320.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.19 expressed in Escherichia coli JM109 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.19 abiraterone
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.19 a C21-steroid + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 a 17alpha-hydroxy-C21-steroid + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.19 pregnenolone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.19 progesterone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens
-
 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.19 Homo sapiens P05093
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.14.19 metal affinity and ion exchange chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.19 a C21-steroid + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens a 17alpha-hydroxy-C21-steroid + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.19 pregnenolone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 17alpha-hydroxypregnenolone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.19 progesterone + [reduced NADPH-hemoprotein reductase] + O2
-
 Homo sapiens 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.19 CYP17A1
-
 Homo sapiens
1.14.14.19 cytochrome P450 17A1
-
 Homo sapiens

General Information

EC Number General Information Comment Organism
1.14.14.19 metabolism the bifunctional enzyme is responsible for pregnenolone C17 hydroxylation, followed by a 17,20-lyase reaction to produce dehydroepiandrosterone, the key intermediate in human synthesis of androgen and estrogen sex steroids Homo sapiens