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Literature summary extracted from

  • Tundo, G.; Sbardella, D.; Ciaccio, C.; Bianculli, A.; Orlandi, A.; Desimio, M.; Arcuri, G.; Coletta, M.; Marini, S.
    Insulin-degrading enzyme (IDE): A novel heat shock-like protein (2013), J. Biol. Chem., 288, 2281-2289.
    View publication on PubMedView publication on EuropePMC

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.56 Zn2+ contains zinc Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.56 110000
-
 x * 110000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.56 amyloid beta-peptide + H2O Homo sapiens
-
 ?
-
 ?
3.4.24.56 insulin + H2O Homo sapiens
-
 ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Homo sapiens P14735
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.56 brain
-
 Homo sapiens
-
3.4.24.56 liver
-
 Homo sapiens
-
3.4.24.56 muscle
-
 Homo sapiens
-
3.4.24.56 SH-SY5Y cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.56 amyloid beta-peptide + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.56 insulin + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.56 ? x * 110000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
3.4.24.56 IDE
-
 Homo sapiens
3.4.24.56 Insulin-degrading enzyme
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.24.56 Homo sapiens all-trans retinoic acid treatment down-regulates enzyme expression in neuroblastoma cells down
3.4.24.56 Homo sapiens enzyme expression is stress-inducible (heat shock at 48°C for 15 and 30 min, increasing concentrations of H2O2, and serum starvation for 60 min) and up-regulated in some central nervous system tumors up

General Information

EC Number General Information Comment Organism
3.4.24.56 malfunction enzyme downregulation impairs SHSY5Y cell proliferation and triggers cell death. Enzyme inhibition is accompanied by a decrease of the poly-ubiquitinated protein content and co-immunoprecipitates with proteasome and ubiquitin in SHSY5Y cells Homo sapiens