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Literature summary extracted from

  • Farizano, J.V.; Pescaretti, M.d.e..L.; Lopez, F.E.; Hsu, F.F.; Delgado, M.A.
    The PmrAB system-inducing conditions control both lipid A remodeling and O-antigen length distribution, influencing the Salmonella typhimurium-host interactions (2012), J. Biol. Chem., 287, 38778-38789.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.43 Salmonella enterica Q8Z1P4 serovar Typhimurium, gene pmrA
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2.7.8.43 Salmonella enterica 14028s Q8Z1P4 serovar Typhimurium, gene pmrA
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Synonyms

EC Number Synonyms Comment Organism
2.7.8.43 PmrA
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 Salmonella enterica

General Information

EC Number General Information Comment Organism
2.7.8.43 malfunction phenotypes of mutants of PmrA-dependent genes pbgE2 and pbgE3, overview Salmonella enterica
2.7.8.43 metabolism under PmrA regulator activation, the expression of wzzfepE and wzzst genes is induced, and their products are required to determine the O-antigen chain length. Wzzst protein is necessary to maintain the balance of 4-aminoarabinose and phosphoethanolamine lipid A modifications. The interaction of the PmrA-dependent pbgE2 and pbgE3 gene products is important for the formation of the short O-antigen region, protein Wzzst is unable to interact with itself or with the PbgE2 or PbgE3 protein Salmonella enterica
2.7.8.43 physiological function PmrAB is the global regulatory system that controls lipopolysaccharide modification, leading to a coordinate regulation of 4-aminoarabinose incorporation and O-antigen chain length to respond against the host defense mechanisms. The PmrAB two-component system consists of the PmrA response regulator and the PmrB sensor, which is able to sense Fe3+, activating the system. The PmrAB two-component system activation promotes a remodeling of lipid A and the core region by addition of 4-aminoarabinose and/or phosphoethanolamine. These PmrA-dependent activities are produced by activation of ugd, pbgPE, pmrC, cpta, and pmrG transcription. Lipid A profiles from wild-type and mutant strains, overview Salmonella enterica