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Literature summary extracted from

  • Ternes, P.; Franke, S.; Zaehringer, U.; Sperling, P.; Heinz, E.
    Identification and characterization of a sphingolipid delta 4-desaturase family (2002), J. Biol. Chem., 277, 25512-25518.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.19.17 expressed in Saccharomyces cerevisiae strain sur2DELTA Caenorhabditis elegans
1.14.19.17 expressed in Saccharomyces cerevisiae strain sur2DELTA Homo sapiens
1.14.19.17 expressed in Saccharomyces cerevisiae strain sur2DELTA Mus musculus
1.14.19.17 expressed in Saccharomyces cerevisiae strain sur2DELTA Drosophila melanogaster
1.14.19.17 expressed in Saccharomyces cerevisiae strain sur2DELTA Candida albicans

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.19.17 membrane
-
 Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.17 dihydroceramide + ferrocytochrome b5 + O2 + H+ Caenorhabditis elegans
-
 (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
 ?
1.14.19.17 dihydroceramide + ferrocytochrome b5 + O2 + H+ Homo sapiens
-
 (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
 ?
1.14.19.17 dihydroceramide + ferrocytochrome b5 + O2 + H+ Mus musculus
-
 (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
 ?
1.14.19.17 dihydroceramide + ferrocytochrome b5 + O2 + H+ Drosophila melanogaster
-
 (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
 ?
1.14.19.17 dihydroceramide + ferrocytochrome b5 + O2 + H+ Candida albicans
-
 (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.18.5 Mus musculus Q8R2F2 bifunctional sphingolipid delta(4)-desaturase/C4-monooxygenase
-
1.14.19.17 Caenorhabditis elegans G5EC63
-
-
1.14.19.17 Candida albicans Q5AJX2
-
-
1.14.19.17 Drosophila melanogaster Q94515
-
-
1.14.19.17 Homo sapiens O15121
-
-
1.14.19.17 Mus musculus O09005
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.19.17 spermatocyte
-
 Caenorhabditis elegans
-
1.14.19.17 spermatocyte
-
 Homo sapiens
-
1.14.19.17 spermatocyte
-
 Mus musculus
-
1.14.19.17 spermatocyte
-
 Drosophila melanogaster
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.18.5 sphinganine ceramide + 2 ferrocytochrome b5 + O2 + 2 H+
-
 Mus musculus 4-hydroxysphinganine ceramide + 2 ferricytochrome b5 + H2O plus (E)-sphing-4-enine ceramide, the (E)-sphing-4-enine/4-hydroxysphinganine ratio is 2.5:1 ?
1.14.19.17 dihydroceramide + ferrocytochrome b5 + O2 + H+
-
 Caenorhabditis elegans (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
 ?
1.14.19.17 dihydroceramide + ferrocytochrome b5 + O2 + H+
-
 Homo sapiens (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
 ?
1.14.19.17 dihydroceramide + ferrocytochrome b5 + O2 + H+
-
 Mus musculus (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
 ?
1.14.19.17 dihydroceramide + ferrocytochrome b5 + O2 + H+
-
 Drosophila melanogaster (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
 ?
1.14.19.17 dihydroceramide + ferrocytochrome b5 + O2 + H+
-
 Candida albicans (4E)-sphing-4-enine ceramide + ferricytochrome b5 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.18.5 DES2
-
 Mus musculus
1.14.18.5 sphingolipid delta(4)-desaturase/C4-monooxygenase
-
 Mus musculus
1.14.19.17 degenerative spermatocyte desaturase
-
 Mus musculus
1.14.19.17 degenerative spermatocyte desaturase
-
 Drosophila melanogaster
1.14.19.17 DES-1
-
 Drosophila melanogaster
1.14.19.17 DES1
-
 Caenorhabditis elegans
1.14.19.17 DES1
-
 Homo sapiens
1.14.19.17 DES1
-
 Mus musculus
1.14.19.17 DES1
-
 Candida albicans
1.14.19.17 dihydroceramide desaturase
-
 Caenorhabditis elegans
1.14.19.17 dihydroceramide desaturase
-
 Homo sapiens
1.14.19.17 dihydroceramide desaturase
-
 Mus musculus
1.14.19.17 dihydroceramide desaturase
-
 Drosophila melanogaster
1.14.19.17 dihydroceramide desaturase
-
 Candida albicans
1.14.19.17 MDES
-
 Mus musculus
1.14.19.17 membrane lipid desaturase
-
 Homo sapiens
1.14.19.17 MLD
-
 Homo sapiens
1.14.19.17 sphingolipid DELTA4-desaturase
-
 Caenorhabditis elegans
1.14.19.17 sphingolipid DELTA4-desaturase
-
 Homo sapiens
1.14.19.17 sphingolipid DELTA4-desaturase
-
 Mus musculus
1.14.19.17 sphingolipid DELTA4-desaturase
-
 Drosophila melanogaster
1.14.19.17 sphingolipid DELTA4-desaturase
-
 Candida albicans

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.17 cytochrome b5
-
 Caenorhabditis elegans
1.14.19.17 cytochrome b5
-
 Homo sapiens
1.14.19.17 cytochrome b5
-
 Mus musculus
1.14.19.17 cytochrome b5
-
 Drosophila melanogaster
1.14.19.17 cytochrome b5
-
 Candida albicans

General Information

EC Number General Information Comment Organism
1.14.19.17 physiological function DELTA4-desaturated sphingolipids provide an early signal necessary to trigger the entry into both meiotic and spermatid differentiation pathways during spermatogenesis Caenorhabditis elegans
1.14.19.17 physiological function DELTA4-desaturated sphingolipids provide an early signal necessary to trigger the entry into both meiotic and spermatid differentiation pathways during spermatogenesis Homo sapiens
1.14.19.17 physiological function DELTA4-desaturated sphingolipids provide an early signal necessary to trigger the entry into both meiotic and spermatid differentiation pathways during spermatogenesis Mus musculus
1.14.19.17 physiological function DELTA4-desaturated sphingolipids provide an early signal necessary to trigger the entry into both meiotic and spermatid differentiation pathways during spermatogenesis Drosophila melanogaster
1.14.19.17 physiological function DELTA4-desaturated sphingolipids provide an early signal necessary to trigger the entry into both meiotic and spermatid differentiation pathways during spermatogenesis Candida albicans