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Literature summary extracted from

  • Haas, A.L.; Bright, P.M.; Jackson, V.E.
    Functional diversity among putative E2 isozymes in the mechanism of ubiquitin-histone ligation (1988), J. Biol. Chem., 263, 13268-13275.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.2.24 0.00083
-
 [histone H2A]-L-lysine E2 enzyme of 20 kDa, pH 7.5, 37°C Oryctolagus cuniculus
2.3.2.24 0.0015
-
 [histone H2B]-L-lysine E2 enzyme of 20 kDa, pH 7.5, 37°C Oryctolagus cuniculus
2.3.2.24 0.0028
-
 [histone H2A]-L-lysine E2 enzyme of 32 kDa, pH 7.5, 37°C Oryctolagus cuniculus
2.3.2.24 0.012
-
 [histone H2B]-L-lysine E2 enzyme of 32 kDa, pH 7.5, 37°C Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
2.3.2.24 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.3.2.24 reticulocyte
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.2.24 S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [histone H1]-L-lysine
-
 Oryctolagus cuniculus [E1 ubiquitin-activating enzyme]-L-cysteine + N6-monoubiquitinyl-[histone H1]-L-lysine significant rates of processive multiple ubiquitination of calf thymus H1 are catalyzed by E2 enzymes of 14 kDa, 20 kDa, and 32 kDa ?
2.3.2.24 S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [histone H2A]-L-lysine
-
 Oryctolagus cuniculus [E1 ubiquitin-activating enzyme]-L-cysteine + N6-monoubiquitinyl-[histone H2A]-L-lysine significant rates of nonprocessive core histone monoubiquitination are catalyzed by E2 enzymes of 14 kDa, 20 kDa, and 32 kDa ?
2.3.2.24 S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [histone H2B]-L-lysine
-
 Oryctolagus cuniculus [E1 ubiquitin-activating enzyme]-L-cysteine + N6-monoubiquitinyl-[histone H2B]-L-lysine significant rates of nonprocessive core histone monoubiquitination are catalyzed by E2 enzymes of 14 kDa, 20 kDa, and 32 kDa ?
2.3.2.24 S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [histone H3]-L-lysine
-
 Oryctolagus cuniculus [E1 ubiquitin-activating enzyme]-L-cysteine + N6-monoubiquitinyl-[histone H3]-L-lysine significant rates of nonprocessive core histone monoubiquitination are catalyzed by E2 enzymes of 14 kDa, 20 kDa, and 32 kDa ?
2.3.2.24 S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [histone H4]-L-lysine
-
 Oryctolagus cuniculus [E1 ubiquitin-activating enzyme]-L-cysteine + N6-monoubiquitinyl-[histone H4]-L-lysine significant rates of nonprocessive core histone monoubiquitination are catalyzed by E2 enzymes of 14 kDa, 20 kDa, and 32 kDa ?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.3.2.24 0.001
-
 [histone H2A]-L-lysine E2 enzyme of 20 kDa, pH 7.5, 37°C Oryctolagus cuniculus
2.3.2.24 0.0013
-
 [histone H2A]-L-lysine E2 enzyme of 32 kDa, pH 7.5, 37°C Oryctolagus cuniculus
2.3.2.24 0.0022
-
 [histone H2B]-L-lysine E2 enzyme of 20 kDa, pH 7.5, 37°C Oryctolagus cuniculus
2.3.2.24 0.0033
-
 [histone H2B]-L-lysine E2 enzyme of 32 kDa, pH 7.5, 37°C Oryctolagus cuniculus