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Literature summary extracted from
- Shedding of kidney injury molecule-1 by membrane-type 1 matrix metalloproteinase (2012), J. Biochem., 152, 425-432.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.80 | BB-94 | - |
Homo sapiens |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.80 | 56000 | - |
x * 56000, SDS-PAGE | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.80 | CD44 + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.80 | Fibronectin + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.80 | growth differentiation factor-1 + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.80 | hepatocyte growth factor activator inhibitor-1 + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.80 | kidney injury molecule-1 + H2O | Homo sapiens | the enzyme cleaves and sheds the substrate's ectodomain | ? | - |
? | |
| 3.4.24.80 | Laminin-1 + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.80 | laminin-5 + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.80 | pro-MMP-2 + H2O | Homo sapiens | - |
MMP-2 + MMP-2 propeptide | - |
? | |
| 3.4.24.80 | stromal cell-derived factor 1 + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.80 | syndecan-1 + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.80 | transforming growth factor-beta + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.80 | Type I collagen + H2O | Homo sapiens | - |
? | - |
? | |
| 3.4.24.80 | Vitronectin + H2O | Homo sapiens | - |
? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.80 | Homo sapiens | P50281 | - |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.80 | HEK-293T cell | - |
Homo sapiens | - |
| 3.4.24.80 | HT-1080 cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.80 | CD44 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | Fibronectin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | Gelatin + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | growth differentiation factor-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | hepatocyte growth factor activator inhibitor-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | kidney injury molecule-1 + H2O | the enzyme cleaves and sheds the substrate's ectodomain | Homo sapiens | ? | - |
? | |
| 3.4.24.80 | Laminin-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | laminin-5 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | pro-MMP-2 + H2O | - |
Homo sapiens | MMP-2 + MMP-2 propeptide | - |
? | |
| 3.4.24.80 | stromal cell-derived factor 1 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | syndecan-1 + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | transforming growth factor-beta + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | Type I collagen + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.24.80 | Vitronectin + H2O | - |
Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.24.80 | ? | x * 56000, SDS-PAGE | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.24.80 | membrane-type 1 matrix metalloproteinase | - |
Homo sapiens |
| 3.4.24.80 | MT1-MMP | - |
Homo sapiens |
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