Literature summary extracted from
Lee, H.; Hsu, F.F.; Turk, J.; Groisman, E.A.
The PmrA-regulated pmrC gene mediates phosphoethanolamine modification of lipid A and polymyxin resistance in Salmonella enterica (2004), J. Bacteriol., 186, 4124-4133.
Activating Compound
EC Number |
Activating Compound |
Comment |
Organism |
Structure |
---|
2.7.8.43 |
additional information |
the PmrA-activated pmrC gene encodes an inner membrane protein that is required for the incorporation of phosphoethanolamine into lipid A and for polymyxin B resistance, mutational analysis, overview |
Salmonella enterica |
|
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
2.7.8.43 |
Salmonella enterica |
Q8Z1P4 |
- |
- |
General Information
EC Number |
General Information |
Comment |
Organism |
---|
2.7.8.43 |
malfunction |
a pbgP/pmrC double mutant resembled a pmrA mutant both in its lipid A profile and in its susceptibility to polymyxin B, mutation of the pmrC gene results in lipid A that lacks phosphoethanolamine. The inactivation of both the pmrC and pbgP genes in the polymyxin B-resistant pmrA505 genetic background reduces polymyxin B resistance to the levels of the pmrA null mutant |
Salmonella enterica |
2.7.8.43 |
metabolism |
the PmrA-activated pmrC gene encodes an inner membrane protein that is required for the incorporation of phosphoethanolamine into lipid A and for polymyxin B resistance. The pbg operon and the pmrC genes are solely responsible for PmrA-regulated polymyxin B resistance, but the pmrC gene is dispensable for resistance to Fe3+ |
Salmonella enterica |
2.7.8.43 |
physiological function |
the PmrA/PmrB regulatory system of Salmonella enterica controls the modification of lipid A with aminoarabinose and phosphoethanolamine, the PmrA-dependent modification of lipid A with aminoarabinose and phosphoethanolamine is responsible for PmrA-regulated polymyxin B resistance |
Salmonella enterica |