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Literature summary extracted from

  • Jamali, H.; Khan, H.A.; Stringer, J.R.; Chowdhury, S.; Ellman, J.A.
    Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method (2015), J. Am. Chem. Soc., 137, 3616-3621.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.3.15 2-chloro-N-[3-(2,5-dioxo-1-phenylimidazolidin-4-yl)propyl]ethanimidamide
-
 Homo sapiens
3.5.3.15 2-chloro-N-[3-(2,5-dioxoimidazolidin-4-yl)propyl]ethanimidamide
-
 Homo sapiens
3.5.3.15 4-(4-{3-[(2-chloroethanimidoyl)amino]propyl}-2,5-dioxoimidazolidin-1-yl)-2-ethoxy-N-(4-methoxyphenyl)benzamide
-
 Homo sapiens
3.5.3.15 4-(4-{3-[(2-chloroethanimidoyl)amino]propyl}-2,5-dioxoimidazolidin-1-yl)-2-methoxy-N-(4-methoxyphenyl)benzamide
-
 Homo sapiens
3.5.3.15 4-(4-{3-[(2-chloroethanimidoyl)amino]propyl}-2,5-dioxoimidazolidin-1-yl)-N-(4-methoxyphenyl)benzamide
-
 Homo sapiens
3.5.3.15 4-(4-{3-[(2-chloroethanimidoyl)amino]propyl}-2,5-dioxoimidazolidin-1-yl)-N-phenylbenzamide
-
 Homo sapiens
3.5.3.15 4-[(2-chloroethanimidoyl)amino]-N-(diphenylmethyl)butanamide
-
 Homo sapiens
3.5.3.15 chloro-N-(3-{1-[(2'-chloro-3'-fluoro[1,1'-biphenyl]-3-yl)methyl]-2,5-dioxoimidazolidin-4-yl}propyl)ethanimidamide
-
 Homo sapiens
3.5.3.15 chloro-N-(3-{1-[(2'-chloro[1,1'-biphenyl]-3-yl)methyl]-2,5-dioxoimidazolidin-4-yl}propyl)ethanimidamide
-
 Homo sapiens
3.5.3.15 chloro-N-(3-{1-[(3'-fluoro[1,1'-biphenyl]-3-yl)methyl]-2,5-dioxoimidazolidin-4-yl}propyl)ethanimidamide
-
 Homo sapiens
3.5.3.15 chloroamidine
-
 Homo sapiens
3.5.3.15 N-(3-{1-[([1,1'-biphenyl]-3-yl)methyl]-2,5-dioxoimidazolidin-4-yl}propyl)(chloro)ethanimidamide
-
 Homo sapiens
3.5.3.15 N-(biphenyl-3-ylmethyl)-4-[(2-chloroethanimidoyl)amino]butanamide
-
 Homo sapiens
3.5.3.15 N-[(1R)-1-(biphenyl-3-yl)ethyl]-4-[(2-chloroethanimidoyl)amino]butanamide
-
 Homo sapiens
3.5.3.15 N-[(1S)-1-(biphenyl-3-yl)ethyl]-4-[(2-chloroethanimidoyl)amino]butanamide
-
 Homo sapiens
3.5.3.15 N-[(3'-bromobiphenyl-3-yl)methyl]-4-[(2-chloroethanimidoyl)amino]butanamide
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.3.15 protein L-arginine + H2O Homo sapiens
-
 protein L-citrulline + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.3.15 Homo sapiens Q9ULW8
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.3.15 1-[3-(2,5-dioxo-1-phenylimidazolidin-4-yl)propyl]guanidine + H2O
-
 Homo sapiens N-[3-(2,5-dioxo-1-phenylimidazolidin-4-yl)propyl]urea + NH3
-
 ?
3.5.3.15 1-[3-(2,5-dioxo-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-3-yl)propyl]guanidine + H2O
-
 Homo sapiens N-[[6-(benzyloxy)-1H-indol-2-yl]methyl]urea + NH3
-
 ?
3.5.3.15 1-[3-(2,5-dioxoimidazolidin-4-yl)propyl]guanidine + H2O
-
 Homo sapiens N-[3-(2,5-dioxoimidazolidin-4-yl)propyl]urea + NH3
-
 ?
3.5.3.15 1-[3-[1-(biphenyl-3-ylmethyl)-2,5-dioxoimidazolidin-4-yl]propyl]guanidine + H2O
-
 Homo sapiens N-(3-[1-[([1,1'-biphenyl]-3-yl)methyl]-2,5-dioxoimidazolidin-4-yl]propyl)urea + NH3
-
 ?
3.5.3.15 1-[[6-(benzyloxy)-1H-indol-2-yl]methyl]guanidine + H2O
-
 Homo sapiens N-[[6-(benzyloxy)-1H-indol-2-yl]methyl]urea + NH3
-
 ?
3.5.3.15 4-carbamimidamido-N-(diphenylmethyl)butanamide + H2O
-
 Homo sapiens 4-(carbamoylamino)-N-(diphenylmethyl)butanamide + NH3
-
 ?
3.5.3.15 4-[4-(3-carbamimidamidopropyl)-2,5-dioxoimidazolidin-1-yl]-2-ethoxy-N-(4-methoxyphenyl)benzamide + H2O
-
 Homo sapiens 4-[4-[3-(carbamoylamino)propyl]-2,5-dioxoimidazolidin-1-yl]-2-ethoxy-N-(4-methoxyphenyl)benzamide + NH3
-
 ?
3.5.3.15 4-[4-(3-carbamimidamidopropyl)-2,5-dioxoimidazolidin-1-yl]-N-(4-methoxyphenyl)benzamide + H2O
-
 Homo sapiens 4-[4-[3-(carbamoylamino)propyl]-2,5-dioxoimidazolidin-1-yl]-N-(4-methoxyphenyl)benzamide + NH3
-
 ?
3.5.3.15 4-[4-(3-carbamimidamidopropyl)-2,5-dioxoimidazolidin-1-yl]-N-phenylbenzamide + H2O
-
 Homo sapiens 4-[4-[3-(carbamoylamino)propyl]-2,5-dioxoimidazolidin-1-yl]-N-phenylbenzamide + NH3
-
 ?
3.5.3.15 4-[4-[3-(carbamoylamino)propyl]-2,5-dioxoimidazolidin-1-yl]-N-(4-methoxyphenyl)benzamide + H2O
-
 Homo sapiens 4-[4-[3-(carbamoylamino)propyl]-2,5-dioxoimidazolidin-1-yl]-2-methoxy-N-(4-methoxyphenyl)benzamide + NH3
-
 ?
3.5.3.15 N-(3-[1-[(2'-chloro-3'-fluoro[1,1'-biphenyl]-3-yl)methyl]-2,5-dioxoimidazolidin-4-yl]propyl)guanidine + H2O
-
 Homo sapiens N-(3-[1-[(2'-chloro-3'-fluoro[1,1'-biphenyl]-3-yl)methyl]-2,5-dioxoimidazolidin-4-yl]propyl)urea + NH3
-
 ?
3.5.3.15 N-(3-[1-[(2'-chloro[1,1'-biphenyl]-3-yl)methyl]-2,5-dioxoimidazolidin-4-yl]propyl)guanidine + H2O
-
 Homo sapiens N-(3-[1-[(2'-chloro[1,1'-biphenyl]-3-yl)methyl]-2,5-dioxoimidazolidin-4-yl]propyl)urea + NH3
-
 ?
3.5.3.15 N-(3-[1-[([1,1'-biphenyl]-3-yl)methyl]-2,5-dioxoimidazolidin-4-yl]propyl)urea + H2O
-
 Homo sapiens N-(3-[1-[(3'-fluoro[1,1'-biphenyl]-3-yl)methyl]-2,5-dioxoimidazolidin-4-yl]propyl)urea + NH3
-
 ?
3.5.3.15 N-(biphenyl-3-ylmethyl)-4-carbamimidamidobutanamide + H2O
-
 Homo sapiens N-[([1,1''-biphenyl]-3-yl)methyl]-4-(carbamoylamino)butanamide + NH3
-
 ?
3.5.3.15 N-[(1R)-1-(biphenyl-3-yl)ethyl]-4-carbamimidamidobutanamide + H2O
-
 Homo sapiens N-[(1R)-1-([1,1''-biphenyl]-3-yl)ethyl]-4-(carbamoylamino)butanamide + NH3
-
 ?
3.5.3.15 N-[(1S)-1-(biphenyl-3-yl)ethyl]-4-carbamimidamidobutanamide + H2O
-
 Homo sapiens N-[(1S)-1-([1,1''-biphenyl]-3-yl)ethyl]-4-(carbamoylamino)butanamide + NH3
-
 ?
3.5.3.15 N-[(3'-bromobiphenyl-3-yl)methyl]-4-carbamimidamidobutanamide + H2O
-
 Homo sapiens N-[(3''-bromo[1,1''-biphenyl]-3-yl)methyl]-4-(carbamoylamino)butanamide + NH3
-
 ?
3.5.3.15 protein L-arginine + H2O
-
 Homo sapiens protein L-citrulline + NH3
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.5.3.15 PAD3
-
 Homo sapiens
3.5.3.15 protein arginine deiminase 3
-
 Homo sapiens