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Literature summary extracted from

  • Mishanina, T.V.; Corcoran, J.M.; Kohen, A.
    Substrate activation in flavin-dependent thymidylate synthase (2014), J. Am. Chem. Soc., 136, 10597-10600.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.148 Thermotoga maritima Q9WYT0
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2.1.1.148 Thermotoga maritima ATCC 43589 Q9WYT0
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-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.148 additional information an initial activation of the pyrimidine substrate by reduced flavin is required for catalysis. A H/D exchange at C5 of dUMP in D2O requires the flavin to be reduced, as observed experimentally. Chemical trapping of reaction intermediates shows the unusual intermediates of further steps Thermotoga maritima ?
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?
2.1.1.148 additional information an initial activation of the pyrimidine substrate by reduced flavin is required for catalysis. A H/D exchange at C5 of dUMP in D2O requires the flavin to be reduced, as observed experimentally. Chemical trapping of reaction intermediates shows the unusual intermediates of further steps Thermotoga maritima ATCC 43589 ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.1.1.148 FDTS
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Thermotoga maritima
2.1.1.148 flavin-dependent thymidylate synthase
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Thermotoga maritima