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Literature summary extracted from

  • Gong, L.; Lai, S.C.; Treerat, P.; Prescott, M.; Adler, B.; Boyce, J.D.; Devenish, R.J.
    Burkholderia pseudomallei type III secretion system cluster 3 ATPase BsaS, a chemotherapeutic target for small-molecule ATPase inhibitors (2015), Infect. Immun., 83, 1276-1285.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
7.4.2.8 drug development the enzyme is a chemotherapeutic target for small-molecule ATPase inhibitors Burkholderia pseudomallei
7.4.2.8 pharmacology the enzyme is a chemotherapeutic target for small-molecule ATPase inhibitors Burkholderia pseudomallei

Protein Variants

EC Number Protein Variants Comment Organism
7.4.2.8 additional information generation of a bsaS deletion mutant, the bsaS deletion mutant is highly attenuated for virulence in BALB/c mice Burkholderia pseudomallei

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.4.2.8 ATPase inhibitor compound 939
-
 Burkholderia pseudomallei

Organism

EC Number Organism UniProt Comment Textmining
7.4.2.8 Burkholderia pseudomallei Q63K25 gene bsaS
-
7.4.2.8 Burkholderia pseudomallei K96243 Q63K25 gene bsaS
-

Synonyms

EC Number Synonyms Comment Organism
7.4.2.8 BsaS
-
 Burkholderia pseudomallei
7.4.2.8 More cf. EC 3.6.3.14 Burkholderia pseudomallei
7.4.2.8 TTSS ATPase
-
 Burkholderia pseudomallei
7.4.2.8 type III secretion system cluster 3 ATPase
-
 Burkholderia pseudomallei

General Information

EC Number General Information Comment Organism
7.4.2.8 malfunction loss of enzyme BsaS function either via direct genetic inactivation or treatment with the inhibitor compound 939 results in increased susceptibility of Burkholderia pseudomallei to microtubule-associated protein light chain 3-associated phagocytosis in infected RAW 264.7 cells, leading to elevated levels of intracellular killing. The bsaS deletion mutant is highly attenuated for virulence in BALB/c mice Burkholderia pseudomallei