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Literature summary extracted from

  • Cullen, T.W.; O'Brien, O.P.; Hendrixson, D.R.; Giles, D.K.; Hobb, R.I.; Thompson, S.A.; Brodbelt, J.S.; Trent, M.S.
    EptC of Campylobacter jejuni mediates phenotypes involved in host interactions and virulence (2013), Infect. Immun., 81, 430-4440.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.43 gene cj0256 or eptC Campylobacter jejuni

Protein Variants

EC Number Protein Variants Comment Organism
2.7.8.43 additional information construction of several enzyme mutant strains, overview Campylobacter jejuni

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.43 diacylphosphatidylethanolamine + flagellar rod protein FlgG Campylobacter jejuni
-
 ?
-
 ?
2.7.8.43 diacylphosphatidylethanolamine + flagellar rod protein FlgG Campylobacter jejuni 81-176
-
 ?
-
 ?
2.7.8.43 diacylphosphatidylethanolamine + lipid A Campylobacter jejuni
-
 diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
 ?
2.7.8.43 diacylphosphatidylethanolamine + lipid A Campylobacter jejuni
-
 diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?
2.7.8.43 diacylphosphatidylethanolamine + lipid A Campylobacter jejuni 81-176
-
 diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
 ?
2.7.8.43 diacylphosphatidylethanolamine + lipid A Campylobacter jejuni 81-176
-
 diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?
2.7.8.43 additional information Campylobacter jejuni enzyme EptC catalyzes the addition of phosphoethanolamine to the first heptose sugar (Hep I) of the inner core oligosaccharide of Campylobacter jejuni lipooligosaccharide ?
-
 ?
2.7.8.43 additional information Campylobacter jejuni 81-176 enzyme EptC catalyzes the addition of phosphoethanolamine to the first heptose sugar (Hep I) of the inner core oligosaccharide of Campylobacter jejuni lipooligosaccharide ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.43 Campylobacter jejuni A0A3X8T8A0 gene cj0256 or eptC
-
2.7.8.43 Campylobacter jejuni 81-176 A0A3X8T8A0 gene cj0256 or eptC
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.43 diacylphosphatidylethanolamine + flagellar rod protein FlgG
-
 Campylobacter jejuni ?
-
 ?
2.7.8.43 diacylphosphatidylethanolamine + flagellar rod protein FlgG
-
 Campylobacter jejuni 81-176 ?
-
 ?
2.7.8.43 diacylphosphatidylethanolamine + lipid A
-
 Campylobacter jejuni diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
 ?
2.7.8.43 diacylphosphatidylethanolamine + lipid A
-
 Campylobacter jejuni 81-176 diacylglycerol + lipid A 1-(2-aminoethyl diphosphate)
-
 ?
2.7.8.43 diacylphosphatidylethanolamine + lipid A
-
 Campylobacter jejuni diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?
2.7.8.43 diacylphosphatidylethanolamine + lipid A
-
 Campylobacter jejuni 81-176 diacylglycerol + lipid A 4'-(2-aminoethyl diphosphate)
-
 ?
2.7.8.43 additional information enzyme EptC catalyzes the addition of phosphoethanolamine to the first heptose sugar (Hep I) of the inner core oligosaccharide of Campylobacter jejuni lipooligosaccharide Campylobacter jejuni ?
-
 ?
2.7.8.43 additional information enzyme EptC catalyzes the addition of phosphoethanolamine to the first heptose sugar (Hep I) of the inner core oligosaccharide of Campylobacter jejuni lipooligosaccharide Campylobacter jejuni 81-176 ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.43 Cj0256
-
 Campylobacter jejuni
2.7.8.43 EptC
-
 Campylobacter jejuni
2.7.8.43 pEtN transferase
-
 Campylobacter jejuni
2.7.8.43 phosphoethanolamine transferase
-
 Campylobacter jejuni

General Information

EC Number General Information Comment Organism
2.7.8.43 malfunction strains lacking gene eptC show decreased commensal colonization of chick ceca and reduced colonization of BALB/cByJ mice compared to wild-type strains Campylobacter jejuni
2.7.8.43 physiological function the enzyme EptC serves a dual role in modifying the flagellar rod protein, FlgG, and the lipid A domain lipooligosaccharide with a pEtN residue. The enzyme also catalyzes the addition of phosphoethanolamine to the first heptose sugar of the inner core oligosaccharide of lipooligosaccharide, a fourth enzymatic target. Modification of Campylobacter jejuni lipid A with phosphoethanolamine results in increased recognition by the human Toll-like receptor 4-myeloid differentiation factor 2 complex, along with providing resistance to relevant mammalian and avian antimicrobial peptides (i.e., defensins). Modification of surface structures with phosphoethanolamine by EptC is key to its ability to promote commensalism in an avian host and to survive in the mammalian gastrointestinal environment. Modification of FlgG is required for efficient flagellar production and motility Campylobacter jejuni