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Literature summary extracted from

  • Pereira, M.G.; Souza, L.L.; Becari, C.; Duarte, D.A.; Camacho, F.R.; Oliveira, J.A.; Gomes, M.D.; Oliveira, E.B.; Salgado, M.C.; Garcia-Cairasco, N.; Costa-Neto, C.M.
    Angiotensin II-independent angiotensin-(1-7) formation in rat hippocampus: involvement of thimet oligopeptidase (2013), Hypertension, 62, 879-885.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.15 angiotensin I + H2O Rattus norvegicus
-
 angiotensin-(1-7) + ?
-
 ?
3.4.24.15 angiotensin I + H2O Rattus norvegicus Wistar
-
 angiotensin-(1-7) + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.15 Rattus norvegicus P24155
-
-
3.4.24.15 Rattus norvegicus Wistar P24155
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.15 brain
-
 Rattus norvegicus
-
3.4.24.15 central nervous system
-
 Rattus norvegicus
-
3.4.24.15 hippocampus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.15 angiotensin I + H2O
-
 Rattus norvegicus angiotensin-(1-7) + ?
-
 ?
3.4.24.15 angiotensin I + H2O
-
 Rattus norvegicus Wistar angiotensin-(1-7) + ?
-
 ?

General Information

EC Number General Information Comment Organism
3.4.24.15 metabolism elevations in the levels of thimet oligopeptidase, Ang-(1-7), and of receptor Mas transcripts are observed in chronically stimulated epileptic rats Rattus norvegicus
3.4.24.15 physiological function angiotensin-(1-7) is the main metabolite of angiotensin I in rat hippocampi, and thimet oligopeptidase is the main enzyme involved in the generation of Ang-(1-7), which binds to the receptor Mas. In the central nervous system specifically, the heptapeptide is involved in learning and memory processes that occur in central limbic regions, such as the hippocampus Rattus norvegicus