EC Number | Cloned (Comment) | Organism |
---|---|---|
3.11.1.1 | gene phnX, the gene is encoded within a degradative operon for the mineralization of 2-aminoethylphosphonic acid (2-AEP, ciliatine) | Klebsiella aerogenes |
3.11.1.1 | gene phnX, the gene is encoded within a degradative operon for the mineralization of 2-aminoethylphosphonic acid (2-AEP, ciliatine) | Salmonella enterica subsp. enterica serovar Typhimurium |
3.11.1.1 | gene phnX, the gene is encoded within a degradative operon for the mineralization of 2-aminoethylphosphonic acid (2-AEP, ciliatine) | Pseudomonas putida |
3.11.1.1 | gene phnX, the gene is encoded within a degradative operon for the mineralization of 2-aminoethylphosphonic acid (2-AEP, ciliatine) | Pseudomonas aeruginosa |
3.11.1.2 | gene phnA, the gene is encoded within an operon whose expression is regulated by a phosphonoacetate-responsive LTTR | Pseudomonas fluorescens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.11.1.1 | phosphonoacetaldehyde + H2O | Klebsiella aerogenes | - |
acetaldehyde + phosphate | - |
? | |
3.11.1.1 | phosphonoacetaldehyde + H2O | Salmonella enterica subsp. enterica serovar Typhimurium | - |
acetaldehyde + phosphate | - |
? | |
3.11.1.1 | phosphonoacetaldehyde + H2O | Pseudomonas putida | - |
acetaldehyde + phosphate | - |
? | |
3.11.1.1 | phosphonoacetaldehyde + H2O | Pseudomonas aeruginosa | - |
acetaldehyde + phosphate | - |
? | |
3.11.1.1 | phosphonoacetaldehyde + H2O | Pseudomonas putida NG2 | - |
acetaldehyde + phosphate | - |
? | |
3.11.1.2 | Phosphonoacetate + H2O | Pseudomonas fluorescens | - |
acetate + phosphate | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.11.1.1 | Klebsiella aerogenes | - |
gene phnX | - |
3.11.1.1 | Pseudomonas aeruginosa | Q9I433 | gene phnX | - |
3.11.1.1 | Pseudomonas putida | Q8RSQ3 | gene phnX | - |
3.11.1.1 | Pseudomonas putida NG2 | Q8RSQ3 | gene phnX | - |
3.11.1.1 | Salmonella enterica subsp. enterica serovar Typhimurium | Q7ZAP3 | gene phnX | - |
3.11.1.2 | Pseudomonas fluorescens | Q51782 | gene phnA | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
3.11.1.1 | additional information | the organism is able to mineralize 2-aminoethyl phosphonate as sole C, N, and P source | Pseudomonas putida | - |
3.11.1.1 | additional information | the organism is able to mineralize 2-aminoethyl phosphonate as sole C, N, and P source | Pseudomonas aeruginosa | - |
3.11.1.1 | additional information | the organism is not capable of utilizing 2-aminoethyl phosphonate as sole carbon and energy source | Klebsiella aerogenes | - |
3.11.1.1 | additional information | the organism is not capable of utilizing 2-aminoethyl phosphonate as sole carbon and energy source | Salmonella enterica subsp. enterica serovar Typhimurium | - |
3.11.1.2 | additional information | the organism is capable of utilizing phosphonoacetate as sole C and P source | Pseudomonas fluorescens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.11.1.1 | phosphonoacetaldehyde + H2O | - |
Klebsiella aerogenes | acetaldehyde + phosphate | - |
? | |
3.11.1.1 | phosphonoacetaldehyde + H2O | - |
Salmonella enterica subsp. enterica serovar Typhimurium | acetaldehyde + phosphate | - |
? | |
3.11.1.1 | phosphonoacetaldehyde + H2O | - |
Pseudomonas putida | acetaldehyde + phosphate | - |
? | |
3.11.1.1 | phosphonoacetaldehyde + H2O | - |
Pseudomonas aeruginosa | acetaldehyde + phosphate | - |
? | |
3.11.1.1 | phosphonoacetaldehyde + H2O | - |
Pseudomonas putida NG2 | acetaldehyde + phosphate | - |
? | |
3.11.1.2 | Phosphonoacetate + H2O | - |
Pseudomonas fluorescens | acetate + phosphate | - |
? | |
3.11.1.2 | Phosphonoacetate + H2O | metal-assisted hydrolytic cleavage of the C-P bond | Pseudomonas fluorescens | acetate + phosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.11.1.1 | phosphonatase | - |
Klebsiella aerogenes |
3.11.1.1 | phosphonatase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
3.11.1.1 | phosphonatase | - |
Pseudomonas putida |
3.11.1.1 | phosphonatase | - |
Pseudomonas aeruginosa |
EC Number | General Information | Comment | Organism |
---|---|---|---|
3.11.1.1 | evolution | the enzyme is a member of the halo acid dehalogenase superfamily. Distribution of phnX homologs within sequenced bacterial genomes, overview | Klebsiella aerogenes |
3.11.1.1 | evolution | the enzyme is a member of the halo acid dehalogenase superfamily. Distribution of phnX homologs within sequenced bacterial genomes, overview | Salmonella enterica subsp. enterica serovar Typhimurium |
3.11.1.1 | evolution | the enzyme is a member of the halo acid dehalogenase superfamily. Distribution of phnX homologs within sequenced bacterial genomes, overview | Pseudomonas putida |
3.11.1.1 | evolution | the enzyme is a member of the halo acid dehalogenase superfamily. Distribution of phnX homologs within sequenced bacterial genomes, overview | Pseudomonas aeruginosa |
3.11.1.1 | metabolism | the enzyme is involved in the phosphonatase pathway of 2-aminoethyl phosphonate degradation also including a 2-AEP:pyruvate aminotransferase (EC 2.6.1.37), encoded by gene phnW, whose products are phosphonoacetaldehyde and alanine. Expression of the operon is substrate-inducible, mediated by the product of an adjacent gene that encodes a LysR-like transcriptional activator, LTTR | Pseudomonas putida |
3.11.1.1 | metabolism | the enzyme is involved in the phosphonatase pathway of 2-aminoethyl phosphonate degradation also including a 2-AEP:pyruvate aminotransferase (EC 2.6.1.37), encoded by gene phnW, whose products are phosphonoacetaldehyde and alanine. Expression of the operon is substrate-inducible, mediated by the product of an adjacent gene that encodes a LysR-like transcriptional activator, LTTR | Pseudomonas aeruginosa |
3.11.1.1 | metabolism | the enzyme is involved in the phosphonatase pathway of 2-aminoethyl phosphonate degradation also including a 2-AEP:pyruvate aminotransferase (EC 2.6.1.37), encoded by gene phnW, whose products are phosphonoacetaldehyde and alanine. Phosphate-starvation-inducible expression of this pathway as a part of the Pho regulon | Klebsiella aerogenes |
3.11.1.1 | metabolism | the enzyme is involved in the phosphonatase pathway of 2-aminoethyl phosphonate degradation also including a 2-AEP:pyruvate aminotransferase (EC 2.6.1.37), encoded by gene phnW, whose products are phosphonoacetaldehyde and alanine. Phosphate-starvation-inducible expression of this pathway as a part of the Pho regulon | Salmonella enterica subsp. enterica serovar Typhimurium |
3.11.1.1 | additional information | the mechanism of C-P bond cleavage by phosphonatase involves the formation of a Schiff base intermediate between a lysine residue at the active site of the enzyme and the phosphonoacetaldehyde carbonyl group, this activates the phosphonate group for attack by an active site nucleophile | Klebsiella aerogenes |
3.11.1.1 | additional information | the mechanism of C-P bond cleavage by phosphonatase involves the formation of a Schiff base intermediate between a lysine residue at the active site of the enzyme and the phosphonoacetaldehyde carbonyl group, this activates the phosphonate group for attack by an active site nucleophile | Salmonella enterica subsp. enterica serovar Typhimurium |
3.11.1.1 | additional information | the mechanism of C-P bond cleavage by phosphonatase involves the formation of a Schiff base intermediate between a lysine residue at the active site of the enzyme and the phosphonoacetaldehyde carbonyl group, this activates the phosphonate group for attack by an active site nucleophile | Pseudomonas putida |
3.11.1.1 | additional information | the mechanism of C-P bond cleavage by phosphonatase involves the formation of a Schiff base intermediate between a lysine residue at the active site of the enzyme and the phosphonoacetaldehyde carbonyl group, this activates the phosphonate group for attack by an active site nucleophile | Pseudomonas aeruginosa |
3.11.1.2 | evolution | the enzyme is a member of the alkaline phosphatase superfamily. Distributionof phnX homologs within sequenced bacterial genomes, overview | Pseudomonas fluorescens |
3.11.1.2 | metabolism | catabolic C-P-bond metabolism in bacteria, and the pathways for the microbial metabolism of phosphonates, overview. The enzyme is involved in the phosphonoacetate catabolism | Pseudomonas fluorescens |