EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.6.1.17 | EDTA | 5 mM, 13.2% residual activity | Myxococcus xanthus | |
3.6.1.17 | glycerol phosphate | 20 mM, 46.1% residual activity | Myxococcus xanthus | |
3.6.1.17 | iodoacetic acid | 10 mM, 58.8% residual activity | Myxococcus xanthus | |
3.6.1.17 | N-ethylmaleimide | 1 mM, 73.8% residual activity | Myxococcus xanthus | |
3.6.1.17 | trisodium phosphate | 20 mM, 24.8% residual activity | Myxococcus xanthus | |
3.6.1.41 | EDTA | 5 mM, 13.2% residual activity; 5 mM, 2.8% residual activity | Myxococcus xanthus | |
3.6.1.41 | glycerol phosphate | 20 mM, 33.4% residual activity; 20 mM, 46.1% residual activity | Myxococcus xanthus | |
3.6.1.41 | iodoacetic acid | 10 mM, 58.8% residual activity | Myxococcus xanthus | |
3.6.1.41 | N-ethylmaleimide | 1 mM, 62.6% residual activity; 1 mM, 73.8% residual activity | Myxococcus xanthus | |
3.6.1.41 | sodium orthovanadate | 1 mM, 6.7% residual activity | Myxococcus xanthus | |
3.6.1.41 | trisodium phosphate | 20 mM, 24.8% residual activity; 20 mM, 6.2% residual activity | Myxococcus xanthus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.6.1.17 | 0.14 | - |
P1,P4-bis(5'-adenosyl)tetraphosphate | pH 8.0, 50°C, presence of 1 mM Mn2+ | Myxococcus xanthus | |
3.6.1.17 | 0.19 | - |
P1,P5-bis(5'-adenosyl)pentaphosphate | pH 8.0, 50°C, presence of 1 mM Mn2+ | Myxococcus xanthus | |
3.6.1.41 | 0.14 | - |
P1,P4-bis(adenosyl)tetraphosphate | pH 8.0, 50°C, presence of 1 mM Mn2+ | Myxococcus xanthus | |
3.6.1.41 | 0.19 | - |
P1,P5-bis(adenosyl)pentaphosphate | pH 8.0, 50°C, presence of 1 mM Mn2+ | Myxococcus xanthus | |
3.6.1.41 | 0.49 | - |
P1,P5-bis(adenosyl)pentaphosphate | pH 8.0, 50°C, presence of 1 mM Co2+ | Myxococcus xanthus | |
3.6.1.41 | 0.86 | - |
P1,P4-bis(adenosyl)tetraphosphate | pH 8.0, 50°C, presence of 1 mM Co2+ | Myxococcus xanthus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.6.1.17 | Co2+ | about 50% of the activity with Mn2+. In the presence of Mn2+, PrpA hydrolyzes P1,P3-bis(5'-adenosyl)tetraphosphate mainly into AMP and ATP, whereas in the presence of Co2+, PrpA hydrolyzes P1,P3-bis(5'-adenosyl)tetraphosphate into two molecules of ADP, reaction of EC 3.6.1.17 | Myxococcus xanthus | |
3.6.1.17 | Mn2+ | best activator. In the presence of Mn2+, PrpA hydrolyzes Ap4A mainly into AMP and ATP, whereas in the presence of Co2+ PrpA hydrolyzes P1,P3-bis(5'-adenosyl)tetraphosphate into two molecules of ADP, reaction of EC 3.6.1.17 | Myxococcus xanthus | |
3.6.1.41 | Co2+ | about 50% of the activity with Mn2+. In the presence of Mn2+, PrpA hydrolyzes P1,P5-bis(adenosyl)tetraphosphate mainly into AMP and ATP, whereas in the presence of Co2+ PrpA hydrolyzes P1,P5-bis(adenosyl)tetraphosphate into two molecules of ADP, reaction of EC 3.6.1.17 | Myxococcus xanthus | |
3.6.1.41 | Co2+ | required for ApnA hydrolysis | Myxococcus xanthus | |
3.6.1.41 | Mn2+ | best activator. In the presence of Mn2+, PrpA hydrolyzes P1,P5-bis(adenosyl)tetraphosphate mainly into AMP and ATP, whereas in the presence of Co2+ PrpA hydrolyzes P1,P5-bis(adenosyl)tetraphosphate into two molecules of ADP, reaction of EC 3.6.1.17 | Myxococcus xanthus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.6.1.17 | Myxococcus xanthus | Q1DC62 | - |
- |
3.6.1.17 | Myxococcus xanthus DK 1622 | Q1DC62 | - |
- |
3.6.1.41 | Myxococcus xanthus | Q1CWE7 | - |
- |
3.6.1.41 | Myxococcus xanthus | Q1DC62 | - |
- |
3.6.1.41 | Myxococcus xanthus DK 1622 | Q1CWE7 | - |
- |
3.6.1.41 | Myxococcus xanthus DK 1622 | Q1DC62 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.6.1.17 | additional information | PrpA exhibits a phosphatase activity towards p-nitrophenyl phosphate, tyrosine phosphopeptide and tyrosine-phosphorylated protein and a weak hydrolase activity towards ATP | Myxococcus xanthus | ? | - |
? | |
3.6.1.17 | additional information | PrpA exhibits a phosphatase activity towards p-nitrophenyl phosphate, tyrosine phosphopeptide and tyrosine-phosphorylated protein and a weak hydrolase activity towards ATP | Myxococcus xanthus DK 1622 | ? | - |
? | |
3.6.1.17 | P1,P4-bis(5'-adenosyl)tetraphosphate + H2O | - |
Myxococcus xanthus | AMP + ATP | in the presence of Mn2+, PrpA hydrolyzes Ap4A mainly into AMP and ATP, whereas in the presence of Co2+ PrpA hydrolyzes Ap4A into two molecules of ADP, reaction of EC 3.6.1.41 | ? | |
3.6.1.17 | P1,P4-bis(5'-adenosyl)tetraphosphate + H2O | - |
Myxococcus xanthus DK 1622 | AMP + ATP | in the presence of Mn2+, PrpA hydrolyzes Ap4A mainly into AMP and ATP, whereas in the presence of Co2+ PrpA hydrolyzes Ap4A into two molecules of ADP, reaction of EC 3.6.1.41 | ? | |
3.6.1.17 | P1,P5-bis(5'-adenosyl)pentaphosphate + H2O | - |
Myxococcus xanthus | AMP + adenosine 5'-tetraphosphate | - |
? | |
3.6.1.17 | P1,P5-bis(5'-adenosyl)pentaphosphate + H2O | - |
Myxococcus xanthus DK 1622 | AMP + adenosine 5'-tetraphosphate | - |
? | |
3.6.1.41 | additional information | enzyme exhibits high phosphatase activity towards 4-nitrophenyl phospahte, and hydrolase activity towards ApnA and ATP | Myxococcus xanthus | ? | - |
? | |
3.6.1.41 | additional information | PrpA exhibits a phosphatase activity towards p-nitrophenyl phosphate, tyrosine phosphopeptide and tyrosine-phosphorylated protein and a weak hydrolase activity towards ATP | Myxococcus xanthus | ? | - |
? | |
3.6.1.41 | additional information | enzyme exhibits high phosphatase activity towards 4-nitrophenyl phospahte, and hydrolase activity towards ApnA and ATP | Myxococcus xanthus DK 1622 | ? | - |
? | |
3.6.1.41 | additional information | PrpA exhibits a phosphatase activity towards p-nitrophenyl phosphate, tyrosine phosphopeptide and tyrosine-phosphorylated protein and a weak hydrolase activity towards ATP | Myxococcus xanthus DK 1622 | ? | - |
? | |
3.6.1.41 | P1,P4-bis(adenosyl)tetraphosphate + H2O | - |
Myxococcus xanthus | 2 ADP | - |
? | |
3.6.1.41 | P1,P4-bis(adenosyl)tetraphosphate + H2O | - |
Myxococcus xanthus | 2 ADP | in the presence of Mn2+, PrpA hydrolyzes Ap4A mainly into AMP and ATP, reaction of EC 3.6.1.17, whereas in the presence of Co2+, PrpA hydrolyzes Ap4A into two molecules of ADP | ? | |
3.6.1.41 | P1,P4-bis(adenosyl)tetraphosphate + H2O | - |
Myxococcus xanthus DK 1622 | 2 ADP | - |
? | |
3.6.1.41 | P1,P4-bis(adenosyl)tetraphosphate + H2O | - |
Myxococcus xanthus DK 1622 | 2 ADP | in the presence of Mn2+, PrpA hydrolyzes Ap4A mainly into AMP and ATP, reaction of EC 3.6.1.17, whereas in the presence of Co2+, PrpA hydrolyzes Ap4A into two molecules of ADP | ? | |
3.6.1.41 | P1,P5-bis(adenosyl)pentaphosphate + H2O | - |
Myxococcus xanthus | ADP + ATP | - |
? | |
3.6.1.41 | P1,P5-bis(adenosyl)pentaphosphate + H2O | - |
Myxococcus xanthus DK 1622 | ADP + ATP | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.6.1.17 | MXAN_1509 | - |
Myxococcus xanthus |
3.6.1.17 | PrpA | - |
Myxococcus xanthus |
3.6.1.41 | APAH | - |
Myxococcus xanthus |
3.6.1.41 | MXAN_1509 | - |
Myxococcus xanthus |
3.6.1.41 | MXAN_7163 | - |
Myxococcus xanthus |
3.6.1.41 | PrpA | - |
Myxococcus xanthus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.6.1.17 | 0.035 | - |
P1,P5-bis(5'-adenosyl)pentaphosphate | pH 8.0, 50°C, presence of 1 mM Mn2+ | Myxococcus xanthus | |
3.6.1.17 | 0.055 | - |
P1,P4-bis(5'-adenosyl)tetraphosphate | pH 8.0, 50°C, presence of 1 mM Mn2+ | Myxococcus xanthus | |
3.6.1.41 | 0.035 | - |
P1,P5-bis(adenosyl)pentaphosphate | pH 8.0, 50°C, presence of 1 mM Mn2+ | Myxococcus xanthus | |
3.6.1.41 | 0.055 | - |
P1,P4-bis(adenosyl)tetraphosphate | pH 8.0, 50°C, presence of 1 mM Mn2+ | Myxococcus xanthus | |
3.6.1.41 | 7.12 | - |
P1,P4-bis(adenosyl)tetraphosphate | pH 8.0, 50°C, presence of 1 mM Co2+ | Myxococcus xanthus | |
3.6.1.41 | 24 | - |
P1,P5-bis(adenosyl)pentaphosphate | pH 8.0, 50°C, presence of 1 mM Co2+ | Myxococcus xanthus |
EC Number | kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.6.1.17 | 0.18 | - |
P1,P5-bis(5'-adenosyl)pentaphosphate | pH 8.0, 50°C, presence of 1 mM Mn2+ | Myxococcus xanthus | |
3.6.1.17 | 0.4 | - |
P1,P4-bis(5'-adenosyl)tetraphosphate | pH 8.0, 50°C, presence of 1 mM Mn2+ | Myxococcus xanthus | |
3.6.1.41 | 0.18 | - |
P1,P5-bis(adenosyl)pentaphosphate | pH 8.0, 50°C, presence of 1 mM Mn2+ | Myxococcus xanthus | |
3.6.1.41 | 0.4 | - |
P1,P4-bis(adenosyl)tetraphosphate | pH 8.0, 50°C, presence of 1 mM Mn2+ | Myxococcus xanthus | |
3.6.1.41 | 8.28 | - |
P1,P4-bis(adenosyl)tetraphosphate | pH 8.0, 50°C, presence of 1 mM Co2+ | Myxococcus xanthus | |
3.6.1.41 | 48.57 | - |
P1,P5-bis(adenosyl)pentaphosphate | pH 8.0, 50°C, presence of 1 mM Co2+ | Myxococcus xanthus |