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Literature summary extracted from

  • Martin, R.; Risacher, C.; Barthel, A.; Jaeger, A.; Schmidt, A.; Richter, S.; Boehl, M.; Preller, M.; Chinthalapudi, K.; Manstein, D.; Gutzeit, H.; Knoelker, H.
    Silver(I)-catalyzed route to pyrroles: synthesis of halogenated pseudilins as allosteric inhibitors for myosin ATPase and x-ray crystal structures of the protein-inhibitor complexes (2014), Eur. J. Org. Chem., 2014, 4487-4505.
No PubMed abstract available

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
5.6.1.8 X-ray crystallographic analysis of the Dictyostelium discoideum myosin-2 motor domain complexes with magnesium(II)-ADP-metavanadate and the three pseudilin inhibitors pentabromopseudilin, pentachloropseudilin, and tribromodichloropseudilin, PDB IDs 2JJ9, 1VOM, and 2XO8 Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.6.1.8 (S)-(-)-blebbistatin
-
 Oryctolagus cuniculus
5.6.1.8 1-(4-methoxyphenyl)-2-phenyl-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2,3,4-tribromo-5-(2-methoxyphenyl)-1-methyl-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2,3,4-tribromo-5-(3,5-dibromo-2-hydroxyphenyl)-1-methyl-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2,3,4-tribromo-5-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2,3,4-tribromo-5-(3,5-dichloro-2-hydroxyphenyl)-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2,3,4-tribromo-5-(3,5-dichloro-2-methoxyphenyl)pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2,3,4-tribromo-5-(3,5-difluoro-2-hydroxyphenyl)-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2,3,4-tribromo-5-(3,5-difluoro-2-methoxyphenyl)-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2,3,4-trichloro-5-(2-methoxyphenyl)-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2,3,4-trichloro-5-(3,5-dichloro-2-methoxyphenyl)-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2,3,4-triiodo-5-(3,5-dichloro-2-methoxyphenyl)pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2,3,4-triiodo-5-(3,5-difluoro-2-methoxyphenyl)-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2,4-dichloro-6-(3,4,5-triiodo-1H-pyrrol-2-yl)phenol
-
 Oryctolagus cuniculus
5.6.1.8 2,4-difluoro-6-(3,4,5-triiodo-1H-pyrrol-2-yl)phenol
-
 Oryctolagus cuniculus
5.6.1.8 2-(2-hydroxyphenyl)-1-methyl-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2-(2-hydroxyphenyl)-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2-(2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2-(2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,5-dihydro-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2-(2-methoxyphenyl)-1-methyl-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2-(2-methoxyphenyl)-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2-(3,5-dibromo-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2-(3,5-dibromo-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,5-dihydro-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2-(3,5-dibromo-2-methoxyphenyl)-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2-(3,5-dichloro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2-(3,5-dichloro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,5-dihydro-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2-(3,5-dichloro-2-methoxyphenyl)-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2-(3,5-difluoro-2-methoxyphenyl)-1-(4-methylbenzene-1-sulfonyl)-2,5-dihydro-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2-(3,5-difluoro-2-methoxyphenyl)-1-(p-tolylsulfonyl)-2,3-dihydro-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2-(3,5-difluoro-2-methoxyphenyl)-1H-pyrrole
-
 Oryctolagus cuniculus
5.6.1.8 2-Methoxybenzaldehyde
-
 Oryctolagus cuniculus
5.6.1.8 3,5-dibromo-2-methoxybenzaldehyde
-
 Oryctolagus cuniculus
5.6.1.8 3,5-dichloro-2-methoxybenzaldehyde
-
 Oryctolagus cuniculus
5.6.1.8 3,5-difluoro-2-methoxybenzaldehyde
-
 Oryctolagus cuniculus
5.6.1.8 4-methoxy-N-[1-phenyl-4-(trimethylsilyl)but-3-yn-1-yl]aniline
-
 Oryctolagus cuniculus
5.6.1.8 additional information pentahalogenated 2-arylpyrrole-type alkaloids pentabromopseudilin and pentachloropseudilin represent a class of isoform-specific allosteric inhibitors of myosin ATPase. Application of the silver(I)-catalyzed cycloisomerization of N-(homopropargyl)toluene-sulfonamides to the total syntheses of the natural products and several non-natural analogues. Inhibitory effect of pentahalogenated pseudilins on myosin ATPase activity, overview Oryctolagus cuniculus
5.6.1.8 N-(2-methoxybenzylidene)-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-(3,5-dibromo-2-methoxybenzylidene)-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-(3,5-dichloro-2-methoxybenzylidene)-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-(3,5-difluoro-2-methoxybenzylidene)-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-benzyl-p-toluenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-[1-(2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-[1-(2-methoxyphenyl)-but-3-ynyl]-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-[1-(2-methoxyphenyl)buta-2,3-dienyl]-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-[1-(3,5-dibromo-2-methoxyphenyl)-2-(trimethylsilyl)buta-2,3-dienyl]-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-[1-(3,5-dibromo-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-[1-(3,5-dibromo-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-[1-(3,5-dibromo-2-methoxyphenyl)buta-2,3-dienyl]-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-[1-(3,5-dichloro-2-methoxyphenyl)-2-(trimethylsilyl)buta-2,3-dienyl]-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-[1-(3,5-dichloro-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-[1-(3,5-dichloro-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-[1-(3,5-dichloro-2-methoxyphenyl)buta-2,3-dienyl]-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-[1-(3,5-difluoro-2-methoxyphenyl)-2-(trimethylsilyl)buta-2,3-dienyl]-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-[1-(3,5-difluoro-2-methoxyphenyl)-4-(trimethylsilyl)but-3-ynyl]-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-[1-(3,5-difluoro-2-methoxyphenyl)-but-3-ynyl]-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-[1-(3,5-difluoro-2-methoxyphenyl)buta-2,3-dien-1-yl]-4-methylbenzene-1-sulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 N-[1-(methoxyphenyl)-2-(trimethylsilyl)-buta-2,3-dienyl]-4-methylbenzenesulfonamide
-
 Oryctolagus cuniculus
5.6.1.8 pentabromopseudilin
-
 Oryctolagus cuniculus
5.6.1.8 pentachloropseudilin
-
 Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
5.6.1.8 Mg2+ required, structure of myosin-2 complex with Mg2+-ADP-metavanadate Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.6.1.8 ATP + H2O + myosin bound to actin filament at position n Oryctolagus cuniculus
-
 ADP + phosphate + myosin bound to actin filament at position n+1
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.6.1.8 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.6.1.8 skeletal muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.6.1.8 ATP + H2O + myosin bound to actin filament at position n
-
 Oryctolagus cuniculus ADP + phosphate + myosin bound to actin filament at position n+1
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.6.1.8 myosin-2 ATPase
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
5.6.1.8 37
-
 assay at Oryctolagus cuniculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.6.1.8 7.5
-
 assay at Oryctolagus cuniculus