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Literature summary extracted from

  • MacGregor, K.A.; Abdel-Hamid, M.K.; Odell, L.R.; Chau, N.; Whiting, A.; Robinson, P.J.; McCluskey, A.
    Development of quinone analogues as dynamin GTPase inhibitors (2014), Eur. J. Med. Chem., 85, 191-206.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.6.5.5 2,5-bis(2-(dimethylamino)ethylamino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2,5-bis(2-(hydroxymethyl)anilino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2,5-bis(2-bromoanilino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2,5-bis(2-carboxyanilino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2,5-bis(3-bromopropylamino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2,5-bis(3-carboxyanilino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2,5-bis(3-hydroxyanilino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2,5-bis(3-methoxyanilino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2,5-bis(3-methoxypropylamino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2,5-bis(4-(hydroxymethyl)phenylamino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2,5-bis(4-carboxyanilino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2,5-bis(4-carboxybenzylamino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2,5-bis(4-hydroxyanilino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2,5-bis(4-hydroxybenzylamino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2,5-bis(4-methoxyanilino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2,5-bis(4-methoxybenzylamino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2,5-bis(hexylamino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2,5-bis(phenylamino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2,5-bis-(benzylamino)-1,4-benzoquinone
-
 Ovis aries
3.6.5.5 2-(2-carboxyanilino)-1,4-naphthoquinone
-
 Ovis aries
3.6.5.5 2-(3-(hydroxymethyl)anilino)-1,4-naphthoquinone
-
 Ovis aries
3.6.5.5 2-(3-hydroxyanilino)-1,4-naphthoquinone
-
 Ovis aries
3.6.5.5 2-(4-(hydroxymethyl)anilino)-1,4-naphthoquinone
-
 Ovis aries
3.6.5.5 2-(4-hydroxyanilino)-1,4-naphthoquinone
-
 Ovis aries
3.6.5.5 2-(4-hydroxybenzylamino)-1,4-naphthoquinone
-
 Ovis aries
3.6.5.5 additional information development of quinone analogues as dynamin GTPase inhibitors, docking study and molecular modelling, overview. No or poor inhibition by 2,5-bis(2-methylanilino)-1,4-benzoquinone, 2,5-bis(2-methoxyanilino)-1,4-benzoquinone, 2,5-bis(3-(hydroxymethyl)phenylamino)-1,4-benzoquinone, 2,5-b+F49is(2-hydroxyethylamino)-1,4-benzoquinone, 2,5-bis(3-hydroxypropylamino)-1,4-benzoquinone, 2,5-bis(4-hydroxybutylamino)-1,4-benzoquinone, 2,5-bis(2-methoxyethylamino)-1,4-benzoquinone, 2,5-bis(2-(methylthio)ethylamino)-1,4-benzoquinone, 2,5-bis(2-chloroethylamino)-1,4-benzoquinone, 2,5-bis(2-bromoethylamino)-1,4-benzoquinone, 2,5-bis(3-chloropropylamino)-1,4-benzoquinone, 2,5-bis(3-pyridylmethylamino)-1,4-benzoquinone, 2,5-bis(4-methylbenzylamino)-1,4-benzoquinone, 2,5-bis(4-fluorobenzylamino)-1,4-benzoquinone, 2,5-bis(4-bromobenzylamino)-1,4-benzoquinone, 2,5-bis(4-chlorobenzylamino)-1,4-benzoquinone, 2,5-bis(phenethylamino)-1,4-benzoquinone, 2,5-bis(ethylamino)-1,4-benzoquinone, 2,5-bis(propylamino)-1,4-benzoquinone, 2,5-bis(butylamino)-1,4-benzoquinone, 2,5-bis(pentylamino)-1,4-benzoquinone, 2,5-bis(isopentylamino)-1,4-benzoquinone, 2,5-bis(allylamino)-1,4-benzoquinone, 2-(2-hydroxyethylamino)-1,4-naphthoquinone, 2-(3-hydroxypropylamino)-1,4-naphthoquinone, 2-(anilino)-1,4-naphthoquinone, 2-(3-carboxyanilino)-1,4-naphthoquinone, 2-(4-carboxyanilino)-1,4-naphthoquinone, 2-(benzylamino)-1,4-naphthoquinone, and 2-(4-methoxybenzylamino)-1,4-naphthoquinone Ovis aries

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.6.5.5 membrane peripheral membrane fraction Ovis aries 16020
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.6.5.5 Mg2+ required Ovis aries

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.6.5.5 GTP + H2O Ovis aries
-
 GDP + phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.6.5.5 Ovis aries
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.6.5.5 native enzyme from sheep brain membrane fraction by affinity chromatography Ovis aries

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.6.5.5 brain
-
 Ovis aries
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.6.5.5 GTP + H2O
-
 Ovis aries GDP + phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.6.5.5 dynamin GTPase
-
 Ovis aries
3.6.5.5 dynamin I GTPase
-
 Ovis aries
3.6.5.5 dynI GTPase
-
 Ovis aries

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.6.5.5 0.0106
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(4-carboxyanilino)-1,4-benzoquinone
3.6.5.5 0.0111
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(4-hydroxyanilino)-1,4-benzoquinone
3.6.5.5 0.0215
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(4-(hydroxymethyl)phenylamino)-1,4-benzoquinone
3.6.5.5 0.0224
-
 pH and temperature not specified in the publication Ovis aries 2-(4-hydroxyanilino)-1,4-naphthoquinone
3.6.5.5 0.0254
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(3-carboxyanilino)-1,4-benzoquinone
3.6.5.5 0.029
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(4-carboxybenzylamino)-1,4-benzoquinone
3.6.5.5 0.0295
-
 pH and temperature not specified in the publication Ovis aries 2-(4-(hydroxymethyl)anilino)-1,4-naphthoquinone
3.6.5.5 0.0303
-
 pH and temperature not specified in the publication Ovis aries 2-(3-(hydroxymethyl)anilino)-1,4-naphthoquinone
3.6.5.5 0.0502
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(2-carboxyanilino)-1,4-benzoquinone
3.6.5.5 0.0579
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(3-hydroxyanilino)-1,4-benzoquinone
3.6.5.5 0.109
-
 pH and temperature not specified in the publication Ovis aries 2-(3-hydroxyanilino)-1,4-naphthoquinone
3.6.5.5 0.112
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(4-hydroxybenzylamino)-1,4-benzoquinone
3.6.5.5 0.116
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(3-methoxypropylamino)-1,4-benzoquinone
3.6.5.5 0.15
-
 pH and temperature not specified in the publication Ovis aries 2-(4-hydroxybenzylamino)-1,4-naphthoquinone
3.6.5.5 0.17
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(4-methoxybenzylamino)-1,4-benzoquinone
3.6.5.5 0.273
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis-(benzylamino)-1,4-benzoquinone
3.6.5.5 0.3
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(hexylamino)-1,4-benzoquinone
3.6.5.5 0.3
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(2-(dimethylamino)ethylamino)-1,4-benzoquinone
3.6.5.5 0.3
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(3-methoxyanilino)-1,4-benzoquinone
3.6.5.5 0.3
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(4-methoxyanilino)-1,4-benzoquinone
3.6.5.5 0.3
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(2-(hydroxymethyl)anilino)-1,4-benzoquinone
3.6.5.5 0.314
-
 pH and temperature not specified in the publication Ovis aries 2-(2-carboxyanilino)-1,4-naphthoquinone
3.6.5.5 0.387
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(2-bromoanilino)-1,4-benzoquinone
3.6.5.5 0.58
-
 pH and temperature not specified in the publication Ovis aries 2,5-bis(3-bromopropylamino)-1,4-benzoquinone