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Literature summary extracted from
- The ABCs of Candida albicans multidrug transporter Cdr1 (2015), Eukaryot. Cell, 14, 1154-1164.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.6.2.2 | curcumin | - |
Candida albicans |  |
| 7.6.2.2 | RC21v3 | potent inhibitor | Candida albicans | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.6.2.2 | membrane | - |
Candida albicans | 16020 | - |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 7.6.2.2 | 16990 | - |
x * 16990, calculated from amino acid sequence | Candida albicans |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.6.2.2 | ATP + H2O + beta-estradiol/in | Candida albicans | - |
ADP + phosphate + beta-estradiol/out | - |
? | |
| 7.6.2.2 | ATP + H2O + corticosterone/in | Candida albicans | - |
ADP + phosphate + corticosterone/out | - |
? | |
| 7.6.2.2 | ATP + H2O + fluconazole/in | Candida albicans | - |
ADP + phosphate + fluconazole/out | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.6.2.2 | Candida albicans | - |
- |
- |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.6.2.2 | ATP + H2O + beta-estradiol/in | - |
Candida albicans | ADP + phosphate + beta-estradiol/out | - |
? | |
| 7.6.2.2 | ATP + H2O + corticosterone/in | - |
Candida albicans | ADP + phosphate + corticosterone/out | - |
? | |
| 7.6.2.2 | ATP + H2O + fluconazole/in | - |
Candida albicans | ADP + phosphate + fluconazole/out | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 7.6.2.2 | ? | x * 16990, calculated from amino acid sequence | Candida albicans |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.6.2.2 | Candida drug resistance 1 protein | - |
Candida albicans |
| 7.6.2.2 | Cdr1p | - |
Candida albicans |
| 7.6.2.2 | multidrug transporter | - |
Candida albicans |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 7.6.2.2 | physiological function | the enzyme is a major player in multidrug resistance | Candida albicans |
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Release 2023.1 (January 2023)
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