BRENDA - Enzyme Database show

Toxic effects of nicotinamide methylation on mouse brain striatum neuronal cells and its relation to manganese

Mori, Y.; Sugawara, A.; Tsuji, M.; Kakamu, T.; Tsuboi, S.; Kanda, H.; Hayakawa, T.; Fukushima, T.; Environ. Health Prev. Med. 17, 371-376 (2012)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
2.1.1.1
Cd2+
-
Mus musculus
2.1.1.1
Cu2+
-
Mus musculus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.1.1.1
cytosol
-
Mus musculus
5829
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
2.1.1.1
additional information
no effect on enzyme activity by Fe2+ and Mn2+, but Mn2+ reduces mouse CD1 brain striatum neuronal cell survival with less than 10% cells surviving at 0.1 mM Mn2+
Mus musculus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
Mus musculus
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
2.1.1.1
Mus musculus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.1
brain
-
Mus musculus
-
2.1.1.1
neuronal cell
CD1 brain striatum neuronal cells
Mus musculus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
-
733737
Mus musculus
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.1.1.1
37
-
assay at
Mus musculus
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.1.1.1
8.6
-
assay at
Mus musculus
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
2.1.1.1
S-adenosyl-L-methionine
-
Mus musculus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
2.1.1.1
S-adenosyl-L-methionine
-
Mus musculus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
2.1.1.1
Cd2+
-
Mus musculus
2.1.1.1
Cu2+
-
Mus musculus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
2.1.1.1
cytosol
-
Mus musculus
5829
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
2.1.1.1
additional information
no effect on enzyme activity by Fe2+ and Mn2+, but Mn2+ reduces mouse CD1 brain striatum neuronal cell survival with less than 10% cells surviving at 0.1 mM Mn2+
Mus musculus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
Mus musculus
-
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
2.1.1.1
brain
-
Mus musculus
-
2.1.1.1
neuronal cell
CD1 brain striatum neuronal cells
Mus musculus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
2.1.1.1
S-adenosyl-L-methionine + nicotinamide
-
733737
Mus musculus
S-adenosyl-L-homocysteine + 1-methylnicotinamide
-
-
-
?
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
2.1.1.1
37
-
assay at
Mus musculus
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
2.1.1.1
8.6
-
assay at
Mus musculus
General Information
EC Number
General Information
Commentary
Organism
2.1.1.1
malfunction
alterations in in vivo enzyme NNMT activity are believed to be negatively associated with gene polymorphism and environmental influences are also considered to be significant
Mus musculus
2.1.1.1
additional information
nicotinamide and 1-methylnicotinamide are neurotoxic, chronic exposure to Mn2+ plays a role in idiopathic Parkinson's disease associated to 1-methylnicotinamide. But no metal-increased NNMT activity can be measured
Mus musculus
General Information (protein specific)
EC Number
General Information
Commentary
Organism
2.1.1.1
malfunction
alterations in in vivo enzyme NNMT activity are believed to be negatively associated with gene polymorphism and environmental influences are also considered to be significant
Mus musculus
2.1.1.1
additional information
nicotinamide and 1-methylnicotinamide are neurotoxic, chronic exposure to Mn2+ plays a role in idiopathic Parkinson's disease associated to 1-methylnicotinamide. But no metal-increased NNMT activity can be measured
Mus musculus