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Literature summary extracted from

  • Bishop, R.E.; Gibbons, H.S.; Guina, T.; Trent, M.S.; Miller, S.I.; Raetz, C.R.
    Transfer of palmitate from phospholipids to lipid A in outer membranes of gram-negative bacteria (2000), EMBO J., 19, 5071-5080.
    View publication on PubMedView publication on EuropePMC

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.3.1.251 membrane outer membrane Escherichia coli 16020
-
2.3.1.251 membrane outer membrane Salmonella enterica subsp. enterica serovar Typhimurium 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.3.1.251 20000
-
 2 * 20000, His-tagged protein, SDS-PAGE Escherichia coli
2.3.1.251 20000
-
 2 * 20000, His-tagged protein, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium
2.3.1.251 40000
-
 His-tagged protein, treated with glutaraldehyde Escherichia coli
2.3.1.251 40000
-
 His-tagged protein, treated with glutaraldehyde Salmonella enterica subsp. enterica serovar Typhimurium

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.251 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X Escherichia coli
-
 2-acyl-sn-glycero-3-phosphocholine + lipid X
-
 ?
2.3.1.251 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X Salmonella enterica subsp. enterica serovar Typhimurium
-
 2-acyl-sn-glycero-3-phosphocholine + lipid X
-
 ?
2.3.1.251 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720
-
 2-acyl-sn-glycero-3-phosphocholine + lipid X
-
 ?
2.3.1.251 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A Escherichia coli
-
 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
 ?
2.3.1.251 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A Salmonella enterica subsp. enterica serovar Typhimurium
-
 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
 ?
2.3.1.251 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720
-
 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
 ?
2.3.1.251 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA Escherichia coli
-
 2-acyl-sn-glycero-3-phosphocholine + lipid IVB
-
 ?
2.3.1.251 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA Salmonella enterica subsp. enterica serovar Typhimurium
-
 2-acyl-sn-glycero-3-phosphocholine + lipid IVB
-
 ?
2.3.1.251 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720
-
 2-acyl-sn-glycero-3-phosphocholine + lipid IVB
-
 ?
2.3.1.251 additional information Escherichia coli PagP transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors with a strong preference for palmitate in the sn1 position. No substrates: sn-1-palmitoyl-2-lyso-phosphatidylcholine or the sn-2/sn-3 isomer of dipalmitoyl phosphatidylcholine ?
-
 ?
2.3.1.251 additional information Salmonella enterica subsp. enterica serovar Typhimurium PagP transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors with a strong preference for palmitate in the sn1 position. No substrates: sn-1-palmitoyl-2-lyso-phosphatidylcholine or the sn-2/sn-3 isomer of dipalmitoyl phosphatidylcholine ?
-
 ?
2.3.1.251 additional information Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 PagP transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors with a strong preference for palmitate in the sn1 position. No substrates: sn-1-palmitoyl-2-lyso-phosphatidylcholine or the sn-2/sn-3 isomer of dipalmitoyl phosphatidylcholine ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.251 Escherichia coli P37001
-
-
2.3.1.251 Salmonella enterica subsp. enterica serovar Typhimurium Q8ZR06
-
-
2.3.1.251 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 Q8ZR06
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
2.3.1.251 7.2
-
 substrate 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine, pH 8.0, temperature not specified in the publication Escherichia coli
2.3.1.251 7.2
-
 substrate 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine, pH 8.0, temperature not specified in the publication Salmonella enterica subsp. enterica serovar Typhimurium
2.3.1.251 9.7
-
 substrate 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine, pH 8.0, temperature not specified in the publication Escherichia coli
2.3.1.251 9.7
-
 substrate 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine, pH 8.0, temperature not specified in the publication Salmonella enterica subsp. enterica serovar Typhimurium
2.3.1.251 18.2
-
 substrate 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphoserine, pH 8.0, temperature not specified in the publication Escherichia coli
2.3.1.251 18.2
-
 substrate 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphoserine, pH 8.0, temperature not specified in the publication Salmonella enterica subsp. enterica serovar Typhimurium
2.3.1.251 23.3
-
 substrate 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphocholine, pH 8.0, temperature not specified in the publication Escherichia coli
2.3.1.251 23.3
-
 substrate 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphocholine, pH 8.0, temperature not specified in the publication Salmonella enterica subsp. enterica serovar Typhimurium
2.3.1.251 29.6
-
 substrate 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, pH 8.0, temperature not specified in the publication Escherichia coli
2.3.1.251 29.6
-
 substrate 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, pH 8.0, temperature not specified in the publication Salmonella enterica subsp. enterica serovar Typhimurium

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.251 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
-
 Escherichia coli 2-palmitoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
 ?
2.3.1.251 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2-palmitoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
 ?
2.3.1.251 1-oleoyl-2-palmitoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 2-palmitoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
 ?
2.3.1.251 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X
-
 Escherichia coli 2-acyl-sn-glycero-3-phosphocholine + lipid X
-
 ?
2.3.1.251 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2-acyl-sn-glycero-3-phosphocholine + lipid X
-
 ?
2.3.1.251 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + 3-O-deacyl lipid X
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 2-acyl-sn-glycero-3-phosphocholine + lipid X
-
 ?
2.3.1.251 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
-
 Escherichia coli 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
 ?
2.3.1.251 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
 ?
2.3.1.251 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 2-acyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
 ?
2.3.1.251 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA
-
 Escherichia coli 2-acyl-sn-glycero-3-phosphocholine + lipid IVB
-
 ?
2.3.1.251 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2-acyl-sn-glycero-3-phosphocholine + lipid IVB
-
 ?
2.3.1.251 1-palmitoyl-2-acyl-sn-glycero-3-phosphocholine + lipid IVA
-
 Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 2-acyl-sn-glycero-3-phosphocholine + lipid IVB
-
 ?
2.3.1.251 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
-
 Escherichia coli 2-oleoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
 ?
2.3.1.251 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2-oleoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
 ?
2.3.1.251 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + hexa-acyl lipid A
-
 Escherichia coli 2-oleoyl-sn-glycero-3-phosphoethanolamine + hepta-acyl lipid A
-
 ?
2.3.1.251 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine + hexa-acyl lipid A
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2-oleoyl-sn-glycero-3-phosphoethanolamine + hepta-acyl lipid A
-
 ?
2.3.1.251 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
-
 Escherichia coli 2-palmitoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
 ?
2.3.1.251 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphocholine + hexa-acyl lipid A
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2-palmitoyl-sn-glycero-3-phosphocholine + hepta-acyl lipid A
-
 ?
2.3.1.251 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphoserine + hexa-acyl lipid A
-
 Escherichia coli 2-palmitoyl-sn-glycero-3-phosphoserine + hepta-acyl lipid A
-
 ?
2.3.1.251 1-palmitoyl-2-palmitoyl-sn-glycero-3-phosphoserine + hexa-acyl lipid A
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2-palmitoyl-sn-glycero-3-phosphoserine + hepta-acyl lipid A
-
 ?
2.3.1.251 additional information PagP transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors with a strong preference for palmitate in the sn1 position. No substrates: sn-1-palmitoyl-2-lyso-phosphatidylcholine or the sn-2/sn-3 isomer of dipalmitoyl phosphatidylcholine Escherichia coli ?
-
 ?
2.3.1.251 additional information PagP transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors with a strong preference for palmitate in the sn1 position. No substrates: sn-1-palmitoyl-2-lyso-phosphatidylcholine or the sn-2/sn-3 isomer of dipalmitoyl phosphatidylcholine Salmonella enterica subsp. enterica serovar Typhimurium ?
-
 ?
2.3.1.251 additional information PagP transfers a palmitate residue from the sn-1 position of a phospholipid to the N-linked hydroxymyristate on the proximal unit of lipid A or its precursors with a strong preference for palmitate in the sn1 position. No substrates: sn-1-palmitoyl-2-lyso-phosphatidylcholine or the sn-2/sn-3 isomer of dipalmitoyl phosphatidylcholine Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 ?
-
 ?

Subunits

EC Number Subunits Comment Organism
2.3.1.251 dimer 2 * 20000, His-tagged protein, SDS-PAGE Escherichia coli
2.3.1.251 dimer 2 * 20000, His-tagged protein, SDS-PAGE Salmonella enterica subsp. enterica serovar Typhimurium

Synonyms

EC Number Synonyms Comment Organism
2.3.1.251 lipid A palmitoyltransferase
-
 Salmonella enterica subsp. enterica serovar Typhimurium
2.3.1.251 PagP
-
 Escherichia coli
2.3.1.251 PagP
-
 Salmonella enterica subsp. enterica serovar Typhimurium