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Literature summary extracted from

  • Sudhahar, V.; Urao, N.; Oshikawa, J.; McKinney, R.D.; Llanos, R.M.; Mercer, J.F.; Ushio-Fukai, M.; Fukai, T.
    Copper transporter ATP7A protects against endothelial dysfunction in type 1 diabetic mice by regulating extracellular superoxide dismutase (2013), Diabetes, 62, 3839-3850.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
7.2.2.8 enzyme overexpression in transgenic mmice Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.2.2.8 membrane
-
 Mus musculus 16020
-

Organism

EC Number Organism UniProt Comment Textmining
7.2.2.8 Mus musculus Q64430
-
-
7.2.2.8 Mus musculus C57/BL6J Q64430
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.2.2.8 aorta
-
 Mus musculus
-
7.2.2.8 blood vessel
-
 Mus musculus
-
7.2.2.8 endothelium
-
 Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
7.2.2.8 ATP7A
-
 Mus musculus
7.2.2.8 copper transporter
-
 Mus musculus

Expression

EC Number Organism Comment Expression
7.2.2.8 Mus musculus copper transporter ATP7A protein expression is significantly reduced in blood vessels from type 1 diabetes mellitus mice down
7.2.2.8 Mus musculus insulin treatment, but not high glucose, increases enzyme ATP7A expression in vascular smooth muscles cells up

General Information

EC Number General Information Comment Organism
7.2.2.8 malfunction role of extracellular superoxide dismutase SOD3 and ATP7A in endothelial dysfunction in type 1 diabetes mellitus. Type 1 diabetes mellitus-induced endothelial dysfunction and decrease of SOD3 activity are rescued in transgenic mice overexpressing the enzyme ATP7A, a copper transporter. Copper transporter ATP7A protein expression is significantly reduced in blood vessels from type 1 diabetes mellitus mice in part due to the insulin deficiency but not high glucose. Transgenic mice overexpressing ATP7A restore type 1 diabetes mellitus-induced impaired SOD3 activity and endothelial function by reducing superoxide levels Mus musculus
7.2.2.8 physiological function the enzyme ATP7A plays a critical role in delivering cofactor copper to extracellular superoxide dismutase SOD3 for its full activation Mus musculus